Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures
This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (<i>n<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/5/1085 |
| _version_ | 1827665926139412480 |
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| author | Luiz Henrique Ferraz Demarchi Larissa Melo Bandeira Deborah Ledesma Taira Marina Castilhos Souza Umaki Zardin Mary Luizia Ibanhes Ana Olivia Pascoto Esposito Larissa Domingues Castilho De Arruda Crhistinne Cavalheiro Maymone Gonçalves Sabrina Moreira dos Santos Weis-Torres Gabriela Alves Cesar Rivaldo Venâncio Da Cunha Tayana Serpa Ortiz Tanaka Marco Antonio Moreira Puga Grazielli Rocha De Rezende Roberta Barbosa Lopes Silvia Naomi de Oliveira Uehara João Renato Rebello Pinho Flair Jose Carrilho Michele Soares Gomes-Gouvêa Ana Rita Coimbra Motta-Castro |
| author_facet | Luiz Henrique Ferraz Demarchi Larissa Melo Bandeira Deborah Ledesma Taira Marina Castilhos Souza Umaki Zardin Mary Luizia Ibanhes Ana Olivia Pascoto Esposito Larissa Domingues Castilho De Arruda Crhistinne Cavalheiro Maymone Gonçalves Sabrina Moreira dos Santos Weis-Torres Gabriela Alves Cesar Rivaldo Venâncio Da Cunha Tayana Serpa Ortiz Tanaka Marco Antonio Moreira Puga Grazielli Rocha De Rezende Roberta Barbosa Lopes Silvia Naomi de Oliveira Uehara João Renato Rebello Pinho Flair Jose Carrilho Michele Soares Gomes-Gouvêa Ana Rita Coimbra Motta-Castro |
| author_sort | Luiz Henrique Ferraz Demarchi |
| collection | DOAJ |
| description | This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (<i>n</i> = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9–14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4–69.4%). In contrast, only 19.2% (CI 95%: 17.6–20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (<i>n</i> = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered. |
| first_indexed | 2024-03-10T01:35:51Z |
| format | Article |
| id | doaj.art-ce39ab85cedb484482d5e9630490e6b1 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T01:35:51Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ce39ab85cedb484482d5e9630490e6b12023-11-23T13:33:05ZengMDPI AGViruses1999-49152022-05-01145108510.3390/v14051085Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control MeasuresLuiz Henrique Ferraz Demarchi0Larissa Melo Bandeira1Deborah Ledesma Taira2Marina Castilhos Souza Umaki Zardin3Mary Luizia Ibanhes4Ana Olivia Pascoto Esposito5Larissa Domingues Castilho De Arruda6Crhistinne Cavalheiro Maymone Gonçalves7Sabrina Moreira dos Santos Weis-Torres8Gabriela Alves Cesar9Rivaldo Venâncio Da Cunha10Tayana Serpa Ortiz Tanaka11Marco Antonio Moreira Puga12Grazielli Rocha De Rezende13Roberta Barbosa Lopes14Silvia Naomi de Oliveira Uehara15João Renato Rebello Pinho16Flair Jose Carrilho17Michele Soares Gomes-Gouvêa18Ana Rita Coimbra Motta-Castro19Laboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilLaboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, BrazilLaboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, BrazilLaboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, BrazilLaboratório Central de Saúde Pública de Mato Grosso do Sul/SES/MS, Campo Grande 79080-320, BrazilSecretaria de Estado de Saúde de Mato Grosso do Sul, Campo Grande 79031-350, BrazilSecretaria de Estado de Saúde de Mato Grosso do Sul, Campo Grande 79031-350, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilInstituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilSecretaria Nacional de Vigilância em Saúde SVS, Ministério da Saúde, Brasília, Distrito Federal 70740-610, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilLaboratory of Clinical Immunology, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, BrazilThis cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (<i>n</i> = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9–14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4–69.4%). In contrast, only 19.2% (CI 95%: 17.6–20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (<i>n</i> = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.https://www.mdpi.com/1999-4915/14/5/1085Hepatitis Bepidemiologyseroprevalencegenotype |
| spellingShingle | Luiz Henrique Ferraz Demarchi Larissa Melo Bandeira Deborah Ledesma Taira Marina Castilhos Souza Umaki Zardin Mary Luizia Ibanhes Ana Olivia Pascoto Esposito Larissa Domingues Castilho De Arruda Crhistinne Cavalheiro Maymone Gonçalves Sabrina Moreira dos Santos Weis-Torres Gabriela Alves Cesar Rivaldo Venâncio Da Cunha Tayana Serpa Ortiz Tanaka Marco Antonio Moreira Puga Grazielli Rocha De Rezende Roberta Barbosa Lopes Silvia Naomi de Oliveira Uehara João Renato Rebello Pinho Flair Jose Carrilho Michele Soares Gomes-Gouvêa Ana Rita Coimbra Motta-Castro Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures Viruses Hepatitis B epidemiology seroprevalence genotype |
| title | Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures |
| title_full | Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures |
| title_fullStr | Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures |
| title_full_unstemmed | Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures |
| title_short | Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures |
| title_sort | hepatitis b virus infection among japanese immigrants and descendants the need to strengthen preventive and control measures |
| topic | Hepatitis B epidemiology seroprevalence genotype |
| url | https://www.mdpi.com/1999-4915/14/5/1085 |
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