Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis
Abstract For many clonally propagated species, the accumulation of somatic mutations is the principal driver of declines in yield and quality. However, somatic mutations may also promote genetic diversification. Thus, elucidating somatic mutation rates and patterns is important to understand the gen...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Evolutionary Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/eva.13486 |
| _version_ | 1811319129562415104 |
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| author | Zeyu Zheng Hongyin Hu Weixiao Lei Jin Zhang Mingjia Zhu Ying Li Xu Zhang Jianchao Ma Dongshi Wan Tao Ma Guangpeng Ren Dafu Ru |
| author_facet | Zeyu Zheng Hongyin Hu Weixiao Lei Jin Zhang Mingjia Zhu Ying Li Xu Zhang Jianchao Ma Dongshi Wan Tao Ma Guangpeng Ren Dafu Ru |
| author_sort | Zeyu Zheng |
| collection | DOAJ |
| description | Abstract For many clonally propagated species, the accumulation of somatic mutations is the principal driver of declines in yield and quality. However, somatic mutations may also promote genetic diversification. Thus, elucidating somatic mutation rates and patterns is important to understand the genetic basis undergirding the emergence of commercially valuable traits and developmental processes. In this study, we studied the effect of short‐time clonal domestication of Populus alba var. pyramidalis, a species that has been propagated by cutting for the last 67 years. We found that: (1) the somatic mutation rate for P. alba var. pyramidalis is 9.24 × 10−9, which is higher than rates observed in related species; (2) there were more mutations near heterozygous regions, and a larger proportion of CpG and CHG sites were associated with somatic mutations, which may be related to the blocking of DNA repair by methylation; and (3) deleterious mutations were not shared by multiple individuals, and all occurred in heterozygous states, demonstrating the strong selective pressures that act against deleterious mutations. Taken together, the results of our study provide a global view of somatic mutation that will aid efforts to understand the genetic basis of commercially valuable traits and to improve clonally breeding species. |
| first_indexed | 2024-04-13T12:36:45Z |
| format | Article |
| id | doaj.art-ce3a4fe63f1640f685ae02a67b40358e |
| institution | Directory Open Access Journal |
| issn | 1752-4571 |
| language | English |
| last_indexed | 2024-04-13T12:36:45Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Evolutionary Applications |
| spelling | doaj.art-ce3a4fe63f1640f685ae02a67b40358e2022-12-22T02:46:38ZengWileyEvolutionary Applications1752-45712022-11-0115111875188710.1111/eva.13486Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalisZeyu Zheng0Hongyin Hu1Weixiao Lei2Jin Zhang3Mingjia Zhu4Ying Li5Xu Zhang6Jianchao Ma7Dongshi Wan8Tao Ma9Guangpeng Ren10Dafu Ru11State Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaKey Laboratory of Bio‐Resource and Eco‐Environment of Ministry of Education, College of Life Sciences, State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaState Key Laboratory of Grassland Agro‐Ecosystems, College of Ecology Lanzhou University Lanzhou ChinaAbstract For many clonally propagated species, the accumulation of somatic mutations is the principal driver of declines in yield and quality. However, somatic mutations may also promote genetic diversification. Thus, elucidating somatic mutation rates and patterns is important to understand the genetic basis undergirding the emergence of commercially valuable traits and developmental processes. In this study, we studied the effect of short‐time clonal domestication of Populus alba var. pyramidalis, a species that has been propagated by cutting for the last 67 years. We found that: (1) the somatic mutation rate for P. alba var. pyramidalis is 9.24 × 10−9, which is higher than rates observed in related species; (2) there were more mutations near heterozygous regions, and a larger proportion of CpG and CHG sites were associated with somatic mutations, which may be related to the blocking of DNA repair by methylation; and (3) deleterious mutations were not shared by multiple individuals, and all occurred in heterozygous states, demonstrating the strong selective pressures that act against deleterious mutations. Taken together, the results of our study provide a global view of somatic mutation that will aid efforts to understand the genetic basis of commercially valuable traits and to improve clonally breeding species.https://doi.org/10.1111/eva.13486clonaldeleteriousheterozygousPopulus alba var. pyramidalissomatic mutation |
| spellingShingle | Zeyu Zheng Hongyin Hu Weixiao Lei Jin Zhang Mingjia Zhu Ying Li Xu Zhang Jianchao Ma Dongshi Wan Tao Ma Guangpeng Ren Dafu Ru Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis Evolutionary Applications clonal deleterious heterozygous Populus alba var. pyramidalis somatic mutation |
| title | Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis |
| title_full | Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis |
| title_fullStr | Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis |
| title_full_unstemmed | Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis |
| title_short | Somatic mutations during rapid clonal domestication of Populus alba var. pyramidalis |
| title_sort | somatic mutations during rapid clonal domestication of populus alba var pyramidalis |
| topic | clonal deleterious heterozygous Populus alba var. pyramidalis somatic mutation |
| url | https://doi.org/10.1111/eva.13486 |
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