Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy
ObjectiveTo investigate the value of the retinal nerve fiber layer (RNFL) thickness in the optic disc and the cross-sectional area (CSA) of lower limb nerves in the diagnosis of diabetic peripheral neuropathy (DPN) separately and in combination.MethodsA total of 140 patients with type 2 diabetes wer...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.938659/full |
| _version_ | 1798028840855928832 |
|---|---|
| author | Weimiao Chen Xiaohong Wu Shilin Li Yan Zhang Yinqiong Huang Yong Zhuang Xuefeng Bai Xiaoyu Chen Xiahong Lin Xiahong Lin |
| author_facet | Weimiao Chen Xiaohong Wu Shilin Li Yan Zhang Yinqiong Huang Yong Zhuang Xuefeng Bai Xiaoyu Chen Xiahong Lin Xiahong Lin |
| author_sort | Weimiao Chen |
| collection | DOAJ |
| description | ObjectiveTo investigate the value of the retinal nerve fiber layer (RNFL) thickness in the optic disc and the cross-sectional area (CSA) of lower limb nerves in the diagnosis of diabetic peripheral neuropathy (DPN) separately and in combination.MethodsA total of 140 patients with type 2 diabetes were enrolled, including 51 patients with DPN (DPN group) and 89 patients without DPN (NDPN group). Clinical data and biochemical parameters were collected. Electromyography/evoked potential instrument was performed for nerve conduction study. Optical coherence tomography was performed to measure the RNFL thickness of the optic disc. Color Doppler ultrasound was performed to measure CSA of lower limb nerves.ResultsThe RNFL thickness was lower and the CSA of the tibial nerve (TN) in the DPN group was larger than that in the NDPN group. The album/urine creatinine ratio, diabetic retinopathy, and CSA of TN at 3 cm were positively correlated with DPN. The RNFL thickness in the superior quadrant of the optic disc was negatively correlated with DPN. For RNFL thickness to diagnose DPN, the area under the curve (AUC) of the superior quadrant was the largest, which was 0.723 (95% confidence interval [CI]: 0.645–0.805), and the best cutoff value was 127.5 μm (70.5% sensitivity, 72.1% specificity). For CSA of TN to diagnose DPN, the AUC of the distance of 5 cm was the largest, which was 0.660 (95% CI: 0.575–0.739), and the best cutoff value was 13.50 mm2 (82.0% sensitivity, 41.6% specificity). For the combined index, the AUC was greater than that of the above two indicators, which was 0.755 (95% CI: 0.664–0.846), and the best cutoff value was 0.376 (64.3% sensitivity, 83.0% specificity).ConclusionsPatients with DPN have a reduction of the RNFL thickness and an increase in the CSA of TN, and these two changes are related to DPN. The RNFL thickness of the optic disc and the CSA of TN can be used as diagnostic indicators of DPN, and the combination of the two indicators has a higher diagnostic value. |
| first_indexed | 2024-04-11T19:14:43Z |
| format | Article |
| id | doaj.art-ce3ae2f7a70844b58f82a9b4c11e48e5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T19:14:43Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ce3ae2f7a70844b58f82a9b4c11e48e52022-12-22T04:07:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.938659938659Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathyWeimiao Chen0Xiaohong Wu1Shilin Li2Yan Zhang3Yinqiong Huang4Yong Zhuang5Xuefeng Bai6Xiaoyu Chen7Xiahong Lin8Xiahong Lin9Department of Clinical Nutrition, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Ultrasound, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Endocrinology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Geriatric Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaObjectiveTo investigate the value of the retinal nerve fiber layer (RNFL) thickness in the optic disc and the cross-sectional area (CSA) of lower limb nerves in the diagnosis of diabetic peripheral neuropathy (DPN) separately and in combination.MethodsA total of 140 patients with type 2 diabetes were enrolled, including 51 patients with DPN (DPN group) and 89 patients without DPN (NDPN group). Clinical data and biochemical parameters were collected. Electromyography/evoked potential instrument was performed for nerve conduction study. Optical coherence tomography was performed to measure the RNFL thickness of the optic disc. Color Doppler ultrasound was performed to measure CSA of lower limb nerves.ResultsThe RNFL thickness was lower and the CSA of the tibial nerve (TN) in the DPN group was larger than that in the NDPN group. The album/urine creatinine ratio, diabetic retinopathy, and CSA of TN at 3 cm were positively correlated with DPN. The RNFL thickness in the superior quadrant of the optic disc was negatively correlated with DPN. For RNFL thickness to diagnose DPN, the area under the curve (AUC) of the superior quadrant was the largest, which was 0.723 (95% confidence interval [CI]: 0.645–0.805), and the best cutoff value was 127.5 μm (70.5% sensitivity, 72.1% specificity). For CSA of TN to diagnose DPN, the AUC of the distance of 5 cm was the largest, which was 0.660 (95% CI: 0.575–0.739), and the best cutoff value was 13.50 mm2 (82.0% sensitivity, 41.6% specificity). For the combined index, the AUC was greater than that of the above two indicators, which was 0.755 (95% CI: 0.664–0.846), and the best cutoff value was 0.376 (64.3% sensitivity, 83.0% specificity).ConclusionsPatients with DPN have a reduction of the RNFL thickness and an increase in the CSA of TN, and these two changes are related to DPN. The RNFL thickness of the optic disc and the CSA of TN can be used as diagnostic indicators of DPN, and the combination of the two indicators has a higher diagnostic value.https://www.frontiersin.org/articles/10.3389/fendo.2022.938659/fulldiabetes mellitusperipheral neuropathyoptical correlation tomographycolor doppler ultrasounddiagnosis |
| spellingShingle | Weimiao Chen Xiaohong Wu Shilin Li Yan Zhang Yinqiong Huang Yong Zhuang Xuefeng Bai Xiaoyu Chen Xiahong Lin Xiahong Lin Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy Frontiers in Endocrinology diabetes mellitus peripheral neuropathy optical correlation tomography color doppler ultrasound diagnosis |
| title | Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy |
| title_full | Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy |
| title_fullStr | Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy |
| title_full_unstemmed | Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy |
| title_short | Optical coherence tomography of the retina combined with color Doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy |
| title_sort | optical coherence tomography of the retina combined with color doppler ultrasound of the tibial nerve in the diagnosis of diabetic peripheral neuropathy |
| topic | diabetes mellitus peripheral neuropathy optical correlation tomography color doppler ultrasound diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.938659/full |
| work_keys_str_mv | AT weimiaochen opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT xiaohongwu opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT shilinli opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT yanzhang opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT yinqionghuang opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT yongzhuang opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT xuefengbai opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT xiaoyuchen opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT xiahonglin opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy AT xiahonglin opticalcoherencetomographyoftheretinacombinedwithcolordopplerultrasoundofthetibialnerveinthediagnosisofdiabeticperipheralneuropathy |