STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION

This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhib...

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Bibliographic Details
Main Authors: Vladimir Yakushev, Nikolaj Filippenko, Irina Kizilova, Mikhail Korokin, Evgeniya Beskhmelnitsyna, Anna Litvinova
Format: Article
Language:English
Published: Belgorod National Research University 2016-03-01
Series:Research Results in Pharmacology
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Online Access:https://rrpharmacology.pensoft.net/article/31039/download/pdf/
Description
Summary:This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.
ISSN:2658-381X