A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes
Objectives: The primary objective was to investigate the correlation of musculoskeletal pain (MSP) intensity with Vitamin D status and glycemic control in patients of type II diabetes mellitus. The secondary objective was to monitor the anxiety and depression levels with Vitamin D supplementation. M...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Pain |
| Subjects: | |
| Online Access: | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2022;volume=36;issue=2;spage=84;epage=89;aulast=Kumar |
| _version_ | 1811276724873199616 |
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| author | Raunak Kumar Nonica Laisram Neelima Jain |
| author_facet | Raunak Kumar Nonica Laisram Neelima Jain |
| author_sort | Raunak Kumar |
| collection | DOAJ |
| description | Objectives: The primary objective was to investigate the correlation of musculoskeletal pain (MSP) intensity with Vitamin D status and glycemic control in patients of type II diabetes mellitus. The secondary objective was to monitor the anxiety and depression levels with Vitamin D supplementation. Methods: A prospective observational cohort study was conducted over a period of 18 months where 100 patients of type II diabetes mellitus with MSP were screened for Vitamin D status and glycemic levels in terms of HbA1c, anxiety, and depression. MSP was assessed by Visual Analog Scale (VAS) score. The patients who were found with Vitamin D levels (<30 ug/dL) were supplemented with Vitamin D and followed at 3 monthly intervals for 6 months for determining the change in MSP, anxiety, and depression scores. Results: After adjusting for the duration of diabetes, HbA1c, and statin therapy, there was no significant correlation between VAS score and Vitamin D (r = −0.133, P = 0.195). After 6 months of Vitamin D supplementation, all cases attained optimal Vitamin D levels of mean (standard deviation [SD]) of 32.5 (4.1) ng/ml as compared to mean (SD) of 23.4 (2.5) ng/ml at baseline (P < 0.0001). Concurrently, there was a significant reduction in the median (range) VAS scores from 6 (2–10) to 4 (0–8), anxiety levels from 11 (7.75–18) to 10 (7–17), and depression levels from 10 (7–15) to 9 (6–14) (P < 0.0001), respectively. Conclusion: There was no significant independent correlation of MSP intensity with Vitamin D levels or glycemic control. However, the supplementation of Vitamin D significantly alleviated MSP in patients with diabetes, with a significant reduction in anxiety and depression among them. |
| first_indexed | 2024-04-13T00:02:50Z |
| format | Article |
| id | doaj.art-ce3c97bbe9294b05abd999d537f825ba |
| institution | Directory Open Access Journal |
| issn | 0970-5333 |
| language | English |
| last_indexed | 2024-04-13T00:02:50Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pain |
| spelling | doaj.art-ce3c97bbe9294b05abd999d537f825ba2022-12-22T03:11:19ZengWolters Kluwer Medknow PublicationsIndian Journal of Pain0970-53332022-01-01362848910.4103/ijpn.ijpn_1_22A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetesRaunak KumarNonica LaisramNeelima JainObjectives: The primary objective was to investigate the correlation of musculoskeletal pain (MSP) intensity with Vitamin D status and glycemic control in patients of type II diabetes mellitus. The secondary objective was to monitor the anxiety and depression levels with Vitamin D supplementation. Methods: A prospective observational cohort study was conducted over a period of 18 months where 100 patients of type II diabetes mellitus with MSP were screened for Vitamin D status and glycemic levels in terms of HbA1c, anxiety, and depression. MSP was assessed by Visual Analog Scale (VAS) score. The patients who were found with Vitamin D levels (<30 ug/dL) were supplemented with Vitamin D and followed at 3 monthly intervals for 6 months for determining the change in MSP, anxiety, and depression scores. Results: After adjusting for the duration of diabetes, HbA1c, and statin therapy, there was no significant correlation between VAS score and Vitamin D (r = −0.133, P = 0.195). After 6 months of Vitamin D supplementation, all cases attained optimal Vitamin D levels of mean (standard deviation [SD]) of 32.5 (4.1) ng/ml as compared to mean (SD) of 23.4 (2.5) ng/ml at baseline (P < 0.0001). Concurrently, there was a significant reduction in the median (range) VAS scores from 6 (2–10) to 4 (0–8), anxiety levels from 11 (7.75–18) to 10 (7–17), and depression levels from 10 (7–15) to 9 (6–14) (P < 0.0001), respectively. Conclusion: There was no significant independent correlation of MSP intensity with Vitamin D levels or glycemic control. However, the supplementation of Vitamin D significantly alleviated MSP in patients with diabetes, with a significant reduction in anxiety and depression among them.http://www.indianjpain.org/article.asp?issn=0970-5333;year=2022;volume=36;issue=2;spage=84;epage=89;aulast=Kumardiabetes mellitusmusculoskeletal painvitamin d |
| spellingShingle | Raunak Kumar Nonica Laisram Neelima Jain A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes Indian Journal of Pain diabetes mellitus musculoskeletal pain vitamin d |
| title | A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes |
| title_full | A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes |
| title_fullStr | A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes |
| title_full_unstemmed | A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes |
| title_short | A prospective study to determine the effect of Vitamin D levels on musculoskeletal pain, anxiety, and depressions in patients with type II diabetes |
| title_sort | prospective study to determine the effect of vitamin d levels on musculoskeletal pain anxiety and depressions in patients with type ii diabetes |
| topic | diabetes mellitus musculoskeletal pain vitamin d |
| url | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2022;volume=36;issue=2;spage=84;epage=89;aulast=Kumar |
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