The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila

The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila

Loss of ESCRT function in Drosophila imaginal discs is known to cause neoplastic overgrowth fueled by mis-regulation of signaling pathways. Its impact on junctional integrity, however, remains obscure. To dissect the events leading to neoplasia, we used transmission electron microscopy (TEM) on wing...

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Bibliographic Details
Main Authors: Hendrik Pannen, Tim Rapp, Thomas Klein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
Retromer
ESCRT
septate junctions
claudins
tight junctions
neoplasia
Online Access:https://elifesciences.org/articles/61866

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