Simvastatin suppresses the proangiogenic microenvironment of human hepatic stellate cells via the Kruppel-like factor 2 pathway

Simvastatin suppresses the proangiogenic microenvironment of human hepatic stellate cells via the Kruppel-like factor 2 pathway

Background and aims: Statins are reported to have a beneficial effect on portal hypertension (PTH); however, the exact mechanism remains unknown. Hepatic stellate cells (HSCs) can be activated by transforming growth factor beta (TGFβ) and play an important role in angiogenesis leading to PTH. Statin...

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Bibliographic Details
Main Authors: Qing Miao, Xiaoqing Zeng, Guifen Ma, Na Li, Yimei Liu, Tiancheng Luo, Jingjing Lian, Shiyao Chen
Format: Article
Language:English
Published: Aran Ediciones 2015-02-01
Series:Revista Espanola de Enfermedades Digestivas
Subjects:
Simvastatin
Angiogenesis
Hepatic stellate cell
Kruppel-like factor 2
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015000200002&lng=en&tlng=en

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