Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
Background: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/4/599 |
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| author | Beatrice Zanella Sara Boccalini Benedetta Bonito Marco Del Riccio Federico Manzi Emilia Tiscione Paolo Bonanni Working Group DHS Working Group AOUMeyer Working Group AUSLTC Angela Bechini |
| author_facet | Beatrice Zanella Sara Boccalini Benedetta Bonito Marco Del Riccio Federico Manzi Emilia Tiscione Paolo Bonanni Working Group DHS Working Group AOUMeyer Working Group AUSLTC Angela Bechini |
| author_sort | Beatrice Zanella |
| collection | DOAJ |
| description | Background: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and compare the obtained results to a previous survey conducted in 2005–2006. Methods: A qualitative measurement of anti-rubella antibodies was performed on 165 sera using the enzyme-linked immunosorbent Assay (ELISA). The anamnestic and vaccination status was also collected. Results: Our study highlighted a very high rubella seroprevalence (85–100%) in our enrolled population. In the vaccinated group (153/165), 98.7% of them were positive to rubella antibodies. Conclusions: Our study showed the highest seroprevalence rate reached in the province of Florence for rubella in the last 15 years, thanks to the several successful vaccination campaigns promoted in the Tuscany region. Our findings in pediatric and adolescent subjects are a key factor in preventing CRS in adult life, specifically in childbearing women. Thus, the set goal will be to keep the awareness about the vaccination for this preventable disease high. |
| first_indexed | 2024-03-10T15:41:48Z |
| format | Article |
| id | doaj.art-ce3f86927f5d448cae51a93a65b380ec |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T15:41:48Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-ce3f86927f5d448cae51a93a65b380ec2023-11-20T16:46:57ZengMDPI AGVaccines2076-393X2020-10-018459910.3390/vaccines8040599Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)Beatrice Zanella0Sara Boccalini1Benedetta Bonito2Marco Del Riccio3Federico Manzi4Emilia Tiscione5Paolo Bonanni6Working Group DHS7Working Group AOUMeyer8Working Group AUSLTC 9Angela Bechini10Department of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyMedical Specialization School of Hygiene and Preventive Medicine, University of Florence, 50134 Florence, ItalyMeyer Children’s Hospital, 50139 Florence, ItalyAUSL Toscana Centro, 50122 Florence, ItalyDepartment of Health Sciences, University of Florence, 50134 Florence, ItalyBackground: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and compare the obtained results to a previous survey conducted in 2005–2006. Methods: A qualitative measurement of anti-rubella antibodies was performed on 165 sera using the enzyme-linked immunosorbent Assay (ELISA). The anamnestic and vaccination status was also collected. Results: Our study highlighted a very high rubella seroprevalence (85–100%) in our enrolled population. In the vaccinated group (153/165), 98.7% of them were positive to rubella antibodies. Conclusions: Our study showed the highest seroprevalence rate reached in the province of Florence for rubella in the last 15 years, thanks to the several successful vaccination campaigns promoted in the Tuscany region. Our findings in pediatric and adolescent subjects are a key factor in preventing CRS in adult life, specifically in childbearing women. Thus, the set goal will be to keep the awareness about the vaccination for this preventable disease high.https://www.mdpi.com/2076-393X/8/4/599rubellaCRSvaccination coveragepediatricadolescentseroprevalence |
| spellingShingle | Beatrice Zanella Sara Boccalini Benedetta Bonito Marco Del Riccio Federico Manzi Emilia Tiscione Paolo Bonanni Working Group DHS Working Group AOUMeyer Working Group AUSLTC Angela Bechini Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) Vaccines rubella CRS vaccination coverage pediatric adolescent seroprevalence |
| title | Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) |
| title_full | Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) |
| title_fullStr | Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) |
| title_full_unstemmed | Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) |
| title_short | Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) |
| title_sort | rubella seroprevalence boost in the pediatric and adolescent population of florence italy as a preventive strategy for congenital rubella syndrome crs |
| topic | rubella CRS vaccination coverage pediatric adolescent seroprevalence |
| url | https://www.mdpi.com/2076-393X/8/4/599 |
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