Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells
As an evidence-based performance, the rising incidence of various ischemic disorders has been observed across many nations. As a result, there is a growing need for the development of more effective regenerative approaches that could serve as main therapeutic strategies for the treatment of these di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.834754/full |
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| author | Saeed Khodayari Saeed Khodayari Saeed Khodayari Hamid Khodayari Hamid Khodayari Hamid Khodayari Somayeh Ebrahimi-Barough Mehdi Khanmohammadi Md Shahidul Islam Miko Vesovic Arash Goodarzi Habibollah Mahmoodzadeh Karim Nayernia Nasser Aghdami Nasser Aghdami Jafar Ai |
| author_facet | Saeed Khodayari Saeed Khodayari Saeed Khodayari Hamid Khodayari Hamid Khodayari Hamid Khodayari Somayeh Ebrahimi-Barough Mehdi Khanmohammadi Md Shahidul Islam Miko Vesovic Arash Goodarzi Habibollah Mahmoodzadeh Karim Nayernia Nasser Aghdami Nasser Aghdami Jafar Ai |
| author_sort | Saeed Khodayari |
| collection | DOAJ |
| description | As an evidence-based performance, the rising incidence of various ischemic disorders has been observed across many nations. As a result, there is a growing need for the development of more effective regenerative approaches that could serve as main therapeutic strategies for the treatment of these diseases. From a cellular perspective, promoted complex inflammatory mechanisms, after inhibition of organ blood flow, can lead to cell death in all tissue types. In this case, using the stem cell technology provides a safe and regenerative approach for ischemic tissue revascularization and functional cell formation. Limb ischemia (LI) is one of the most frequent ischemic disease types and has been shown to have a promising regenerative response through stem cell therapy based on several clinical trials. Bone marrow-derived mononuclear cells (BM-MNCs), peripheral blood CD34-positive mononuclear cells (CD34+ PB-MNCs), mesenchymal stem cells (MSCs), and endothelial stem/progenitor cells (ESPCs) are the main, well-examined stem cell types in these studies. Additionally, our investigations reveal that endometrial tissue can be considered a suitable candidate for isolating new safe, effective, and feasible multipotent stem cells for limb regeneration. In addition to other teams’ results, our in-depth studies on endometrial-derived stem cells (EnSCs) have shown that these cells have translational potential for limb ischemia treatment. The EnSCs are able to generate diverse types of cells which are essential for limb reconstruction, including endothelial cells, smooth muscle cells, muscle cells, and even peripheral nervous system populations. Hence, the main object of this review is to present stem cell technology and evaluate its method of regeneration in ischemic limb tissue. |
| first_indexed | 2024-04-12T17:22:59Z |
| format | Article |
| id | doaj.art-ce40914e66aa4e81b19d34766f3d763d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T17:22:59Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ce40914e66aa4e81b19d34766f3d763d2022-12-22T03:23:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.834754834754Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem CellsSaeed Khodayari0Saeed Khodayari1Saeed Khodayari2Hamid Khodayari3Hamid Khodayari4Hamid Khodayari5Somayeh Ebrahimi-Barough6Mehdi Khanmohammadi7Md Shahidul Islam8Miko Vesovic9Arash Goodarzi10Habibollah Mahmoodzadeh11Karim Nayernia12Nasser Aghdami13Nasser Aghdami14Jafar Ai15Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, IranBreast Disease Research Center, Tehran University of Medical Sciences, Tehran, IranInternational Center for Personalized Medicine (P7MEDICINE), Düsseldorf, GermanyBreast Disease Research Center, Tehran University of Medical Sciences, Tehran, IranInternational Center for Personalized Medicine (P7MEDICINE), Düsseldorf, GermanyDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranTissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, IranSkull Base Research Center, The Five Senses Institute, School of Medicine, Iran University of Medical Sciences, Tehran, IranTissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, IranDepartment of Mathematics, Statistics, and Computer Science, University of Illinois at Chicago, Chicago, IL, United StatesTissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, IranBreast Disease Research Center, Tehran University of Medical Sciences, Tehran, IranInternational Center for Personalized Medicine (P7MEDICINE), Düsseldorf, GermanyDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranDepartment of Infectious Diseases and Tropical Medicines, Tehran University of Medical Sciences, Tehran, IranTissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Science, Tehran, IranAs an evidence-based performance, the rising incidence of various ischemic disorders has been observed across many nations. As a result, there is a growing need for the development of more effective regenerative approaches that could serve as main therapeutic strategies for the treatment of these diseases. From a cellular perspective, promoted complex inflammatory mechanisms, after inhibition of organ blood flow, can lead to cell death in all tissue types. In this case, using the stem cell technology provides a safe and regenerative approach for ischemic tissue revascularization and functional cell formation. Limb ischemia (LI) is one of the most frequent ischemic disease types and has been shown to have a promising regenerative response through stem cell therapy based on several clinical trials. Bone marrow-derived mononuclear cells (BM-MNCs), peripheral blood CD34-positive mononuclear cells (CD34+ PB-MNCs), mesenchymal stem cells (MSCs), and endothelial stem/progenitor cells (ESPCs) are the main, well-examined stem cell types in these studies. Additionally, our investigations reveal that endometrial tissue can be considered a suitable candidate for isolating new safe, effective, and feasible multipotent stem cells for limb regeneration. In addition to other teams’ results, our in-depth studies on endometrial-derived stem cells (EnSCs) have shown that these cells have translational potential for limb ischemia treatment. The EnSCs are able to generate diverse types of cells which are essential for limb reconstruction, including endothelial cells, smooth muscle cells, muscle cells, and even peripheral nervous system populations. Hence, the main object of this review is to present stem cell technology and evaluate its method of regeneration in ischemic limb tissue.https://www.frontiersin.org/articles/10.3389/fcell.2022.834754/fullstem cell therapylimb ischemiastate-of-artperspectivemolecular mechanismendometrial-derived stem cells |
| spellingShingle | Saeed Khodayari Saeed Khodayari Saeed Khodayari Hamid Khodayari Hamid Khodayari Hamid Khodayari Somayeh Ebrahimi-Barough Mehdi Khanmohammadi Md Shahidul Islam Miko Vesovic Arash Goodarzi Habibollah Mahmoodzadeh Karim Nayernia Nasser Aghdami Nasser Aghdami Jafar Ai Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells Frontiers in Cell and Developmental Biology stem cell therapy limb ischemia state-of-art perspective molecular mechanism endometrial-derived stem cells |
| title | Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells |
| title_full | Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells |
| title_fullStr | Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells |
| title_full_unstemmed | Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells |
| title_short | Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells |
| title_sort | stem cell therapy in limb ischemia state of art perspective and possible impacts of endometrial derived stem cells |
| topic | stem cell therapy limb ischemia state-of-art perspective molecular mechanism endometrial-derived stem cells |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.834754/full |
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