In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection.

In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection.

Numerous in vitro studies have shown that toll-like receptor signaling induces 25-hydroxyvitamin D(3) 1α-hydroxylase (1α-OHase; CYP27B1) expression in macrophages from various species. 1α-OHase is the primary enzyme that converts 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))...

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Bibliographic Details
Main Authors: Corwin D Nelson, Timothy A Reinhardt, Donald C Beitz, John D Lippolis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2993969?pdf=render

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http://europepmc.org/articles/PMC2993969?pdf=render

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