Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone
Abstract Background Intermittent Preventive Treatment of malaria in infants (IPTi) is a malaria control strategy consisting of the administration of an anti-malarial drug alongside routine immunizations. So far, this is being implemented nationwide in Sierra Leone only. IPTi has been renamed as Pere...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Malaria Journal |
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| Online Access: | https://doi.org/10.1186/s12936-023-04575-6 |
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| author | Augustin E. Fombah Haily Chen Kwabena Owusu-Kyei Llorenç Quinto Raquel Gonzalez Julian Williams Mireia LLach Berne Myrte Wassenaar Abubakarr Jalloh Joe-Henry C. Sunders Maximo Ramirez Cesc Bertran-Cobo Francisco Saute Didier K. Ekouevi Valérie Briand Anitta R. Y. Kamara Tom Sesay Mohamed Samai Clara Menendez |
| author_facet | Augustin E. Fombah Haily Chen Kwabena Owusu-Kyei Llorenç Quinto Raquel Gonzalez Julian Williams Mireia LLach Berne Myrte Wassenaar Abubakarr Jalloh Joe-Henry C. Sunders Maximo Ramirez Cesc Bertran-Cobo Francisco Saute Didier K. Ekouevi Valérie Briand Anitta R. Y. Kamara Tom Sesay Mohamed Samai Clara Menendez |
| author_sort | Augustin E. Fombah |
| collection | DOAJ |
| description | Abstract Background Intermittent Preventive Treatment of malaria in infants (IPTi) is a malaria control strategy consisting of the administration of an anti-malarial drug alongside routine immunizations. So far, this is being implemented nationwide in Sierra Leone only. IPTi has been renamed as Perennial Malaria Chemoprevention -PMC-, accounting for its recently recommended expansion into the second year of life. Before starting a pilot implementation on PMC, the currently implemented strategy and malaria prevalence were assessed in young children in selected areas of Sierra Leone. Methods A cross-sectional, community-based, multi-stage cluster household survey was conducted from November to December 2021 in selected districts of the Northern and northwestern provinces of Sierra Leone among 10–23 months old children, whose caretakers gave written informed consent to participate in the survey. Coverage of IPTi and malaria prevalence—assessed with rapid diagnostic tests—were calculated using percentages and 95% confidence intervals weighted for the sampling design and adjusted for non-response within clusters. Factors associated with RDT + and iPTi coverage were also assessed. Results A total of 720 children were recruited. Coverage of three IPTi doses was 50.57% (368/707; 95% CI 45.38–55.75), while prevalence of malaria infection was 28.19% (95% CI 24.81–31.84). Most children had received IPTi1 (80.26%, 574/707; 95% CI 75.30–84.44), and IPTi2 (80.09%, 577/707; 95% CI 76.30–83.40) and over half of the children also received IPTi3 (57.72%, 420/707; 95% CI 53.20–62.11). The uptake of each IPTi dose was lower than that of the vaccines administered at the same timepoint at all contacts. Conclusion In Sierra Leone, half of the children received the three recommended doses of IPTi indicating an increase in its uptake compared to previous data of just a third of children receiving the intervention. However, efforts need to be made in improving IPTi coverage, especially in the planned expansion of the strategy into the second year of life following recent WHO guidelines. |
| first_indexed | 2024-04-09T14:04:48Z |
| format | Article |
| id | doaj.art-ce43cec757f2401785934cc178ca2dbc |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-09T14:04:48Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-ce43cec757f2401785934cc178ca2dbc2023-05-07T11:06:16ZengBMCMalaria Journal1475-28752023-05-0122111210.1186/s12936-023-04575-6Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra LeoneAugustin E. Fombah0Haily Chen1Kwabena Owusu-Kyei2Llorenç Quinto3Raquel Gonzalez4Julian Williams5Mireia LLach Berne6Myrte Wassenaar7Abubakarr Jalloh8Joe-Henry C. Sunders9Maximo Ramirez10Cesc Bertran-Cobo11Francisco Saute12Didier K. Ekouevi13Valérie Briand14Anitta R. Y. Kamara15Tom Sesay16Mohamed Samai17Clara Menendez18Barcelona Institute for Global Health, Hospital Clinic-University of BarcelonaBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaCollege of Medicine and Allied Health Sciences, University of Sierra LeoneBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaCollege of Medicine and Allied Health Sciences, University of Sierra LeoneCollege of Medicine and Allied Health Sciences, University of Sierra LeoneBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaManhiça Health Research CenterUniversité de LoméNational Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Centre, University of BordeauxNational Malaria Control Program, Directorate of Disease Prevention and Control, Ministry of Health and SanitationDirectorate of Research and Training, Ministry of Health and SanitationCollege of Medicine and Allied Health Sciences, University of Sierra LeoneBarcelona Institute for Global Health, Hospital Clinic-University of BarcelonaAbstract Background Intermittent Preventive Treatment of malaria in infants (IPTi) is a malaria control strategy consisting of the administration of an anti-malarial drug alongside routine immunizations. So far, this is being implemented nationwide in Sierra Leone only. IPTi has been renamed as Perennial Malaria Chemoprevention -PMC-, accounting for its recently recommended expansion into the second year of life. Before starting a pilot implementation on PMC, the currently implemented strategy and malaria prevalence were assessed in young children in selected areas of Sierra Leone. Methods A cross-sectional, community-based, multi-stage cluster household survey was conducted from November to December 2021 in selected districts of the Northern and northwestern provinces of Sierra Leone among 10–23 months old children, whose caretakers gave written informed consent to participate in the survey. Coverage of IPTi and malaria prevalence—assessed with rapid diagnostic tests—were calculated using percentages and 95% confidence intervals weighted for the sampling design and adjusted for non-response within clusters. Factors associated with RDT + and iPTi coverage were also assessed. Results A total of 720 children were recruited. Coverage of three IPTi doses was 50.57% (368/707; 95% CI 45.38–55.75), while prevalence of malaria infection was 28.19% (95% CI 24.81–31.84). Most children had received IPTi1 (80.26%, 574/707; 95% CI 75.30–84.44), and IPTi2 (80.09%, 577/707; 95% CI 76.30–83.40) and over half of the children also received IPTi3 (57.72%, 420/707; 95% CI 53.20–62.11). The uptake of each IPTi dose was lower than that of the vaccines administered at the same timepoint at all contacts. Conclusion In Sierra Leone, half of the children received the three recommended doses of IPTi indicating an increase in its uptake compared to previous data of just a third of children receiving the intervention. However, efforts need to be made in improving IPTi coverage, especially in the planned expansion of the strategy into the second year of life following recent WHO guidelines.https://doi.org/10.1186/s12936-023-04575-6Malaria preventionChild healthIPTiPMCSub-Saharan AfricaSierra Leone |
| spellingShingle | Augustin E. Fombah Haily Chen Kwabena Owusu-Kyei Llorenç Quinto Raquel Gonzalez Julian Williams Mireia LLach Berne Myrte Wassenaar Abubakarr Jalloh Joe-Henry C. Sunders Maximo Ramirez Cesc Bertran-Cobo Francisco Saute Didier K. Ekouevi Valérie Briand Anitta R. Y. Kamara Tom Sesay Mohamed Samai Clara Menendez Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone Malaria Journal Malaria prevention Child health IPTi PMC Sub-Saharan Africa Sierra Leone |
| title | Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone |
| title_full | Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone |
| title_fullStr | Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone |
| title_full_unstemmed | Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone |
| title_short | Coverage of intermittent preventive treatment of malaria in infants after four years of implementation in Sierra Leone |
| title_sort | coverage of intermittent preventive treatment of malaria in infants after four years of implementation in sierra leone |
| topic | Malaria prevention Child health IPTi PMC Sub-Saharan Africa Sierra Leone |
| url | https://doi.org/10.1186/s12936-023-04575-6 |
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