The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides
A short route to the synthesis of analogues of the antifungal but unstable natural product crocacin D was developed. A wide range of compounds were made in which the complex side chain was replaced by simple aromatic units, and many of them showed high activity in a mitochondrial beef hear...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2003-11-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/3768 |
| _version_ | 1828097611812306944 |
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| author | Patrick J. Crowley Paul A. Worthington Joe Swanborough Olivia-Anabelle Sageot Gordon R. Munns Ingrid M. Devillers Christopher R.A. Godfrey Kevin Gillen Ian H. Aspinall John Williams |
| author_facet | Patrick J. Crowley Paul A. Worthington Joe Swanborough Olivia-Anabelle Sageot Gordon R. Munns Ingrid M. Devillers Christopher R.A. Godfrey Kevin Gillen Ian H. Aspinall John Williams |
| author_sort | Patrick J. Crowley |
| collection | DOAJ |
| description |
A short route to the synthesis of analogues of the antifungal but unstable natural product crocacin D was developed. A wide range of compounds were made in which the complex side chain was replaced by simple aromatic units, and many of them showed high activity in a mitochondrial beef
heart respiration assay. Some of these compounds were active against plant pathogenic fungi of agricultural importance in glasshouse tests. In order to find compounds with greater stability than the natural crocacins, the photolabile (Z)-enamide was replaced with many different moieties,
but none gave rise to useful fungicidal activity.
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| first_indexed | 2024-04-11T07:49:48Z |
| format | Article |
| id | doaj.art-ce4462af8a9c4393b7d93b704a723d30 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-11T07:49:48Z |
| publishDate | 2003-11-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-ce4462af8a9c4393b7d93b704a723d302022-12-22T04:36:08ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242003-11-01571110.2533/000942903777678669The Crocacins: Novel Natural Products as Leads for Agricultural FungicidesPatrick J. CrowleyPaul A. WorthingtonJoe SwanboroughOlivia-Anabelle SageotGordon R. MunnsIngrid M. DevillersChristopher R.A. GodfreyKevin GillenIan H. AspinallJohn Williams A short route to the synthesis of analogues of the antifungal but unstable natural product crocacin D was developed. A wide range of compounds were made in which the complex side chain was replaced by simple aromatic units, and many of them showed high activity in a mitochondrial beef heart respiration assay. Some of these compounds were active against plant pathogenic fungi of agricultural importance in glasshouse tests. In order to find compounds with greater stability than the natural crocacins, the photolabile (Z)-enamide was replaced with many different moieties, but none gave rise to useful fungicidal activity. https://chimia.ch/chimia/article/view/3768AgrochemicalCrocacinFungicideNatural productRespiration |
| spellingShingle | Patrick J. Crowley Paul A. Worthington Joe Swanborough Olivia-Anabelle Sageot Gordon R. Munns Ingrid M. Devillers Christopher R.A. Godfrey Kevin Gillen Ian H. Aspinall John Williams The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides CHIMIA Agrochemical Crocacin Fungicide Natural product Respiration |
| title | The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides |
| title_full | The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides |
| title_fullStr | The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides |
| title_full_unstemmed | The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides |
| title_short | The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides |
| title_sort | crocacins novel natural products as leads for agricultural fungicides |
| topic | Agrochemical Crocacin Fungicide Natural product Respiration |
| url | https://chimia.ch/chimia/article/view/3768 |
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