Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell
Phagocytosis of dying cells constitutes an importance mechanism of antigen capture for the cross-priming of CD8+ T cells. This process has been shown to be critical for achieving tumor and viral immunity. While most studies have focused on the mechanisms inherent in the dendritic cell that account f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00061/full |
| _version_ | 1818560375600185344 |
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| author | Matthew eAlbert Pierre-Emmanuel eJoubert |
| author_facet | Matthew eAlbert Pierre-Emmanuel eJoubert |
| author_sort | Matthew eAlbert |
| collection | DOAJ |
| description | Phagocytosis of dying cells constitutes an importance mechanism of antigen capture for the cross-priming of CD8+ T cells. This process has been shown to be critical for achieving tumor and viral immunity. While most studies have focused on the mechanisms inherent in the dendritic cell that account for exogenous antigen accessing MHC I, several recent reports have highlighted the important contribution made by the antigen donor cell. Specifically, the cell stress and cell death pathways that precede antigen transfer are now known to impact cross-presentation and cross-priming. Herein, we review the current literature regarding a role for macro-autophagy within the antigen donor cell. Further examination of this point of immune regulation is warranted and may contribute to a better understanding of how to optimize immunotherapy for treatment of cancer and chronic infectious disease. |
| first_indexed | 2024-12-14T00:37:42Z |
| format | Article |
| id | doaj.art-ce446e1fffee422cb2a0850b1f755cdf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T00:37:42Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ce446e1fffee422cb2a0850b1f755cdf2022-12-21T23:24:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-03-01310.3389/fimmu.2012.0006122892Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cellMatthew eAlbert0Pierre-Emmanuel eJoubert1Institut PasteurInstitut PasteurPhagocytosis of dying cells constitutes an importance mechanism of antigen capture for the cross-priming of CD8+ T cells. This process has been shown to be critical for achieving tumor and viral immunity. While most studies have focused on the mechanisms inherent in the dendritic cell that account for exogenous antigen accessing MHC I, several recent reports have highlighted the important contribution made by the antigen donor cell. Specifically, the cell stress and cell death pathways that precede antigen transfer are now known to impact cross-presentation and cross-priming. Herein, we review the current literature regarding a role for macro-autophagy within the antigen donor cell. Further examination of this point of immune regulation is warranted and may contribute to a better understanding of how to optimize immunotherapy for treatment of cancer and chronic infectious disease.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00061/fullAutophagyCell DeathCross-PrimingDendritic Cellsantigen presenting cellstumor immunity |
| spellingShingle | Matthew eAlbert Pierre-Emmanuel eJoubert Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell Frontiers in Immunology Autophagy Cell Death Cross-Priming Dendritic Cells antigen presenting cells tumor immunity |
| title | Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell |
| title_full | Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell |
| title_fullStr | Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell |
| title_full_unstemmed | Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell |
| title_short | Antigen cross-priming of cell-associated proteins is enhanced by macroautophagy within the antigen donor cell |
| title_sort | antigen cross priming of cell associated proteins is enhanced by macroautophagy within the antigen donor cell |
| topic | Autophagy Cell Death Cross-Priming Dendritic Cells antigen presenting cells tumor immunity |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00061/full |
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