Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis
Objective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro. It were used to predict the material basis and potential mechanism of Citrus peel in the treat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
The editorial department of Science and Technology of Food Industry
2024-03-01
|
| Series: | Shipin gongye ke-ji |
| Subjects: | |
| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023010158 |
| _version_ | 1797294361853034496 |
|---|---|
| author | Yan ZHANG Ping YAN Hua ZHANG Han ZHANG Mengdi ZHENG Xiyan CHAI |
| author_facet | Yan ZHANG Ping YAN Hua ZHANG Han ZHANG Mengdi ZHENG Xiyan CHAI |
| author_sort | Yan ZHANG |
| collection | DOAJ |
| description | Objective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro. It were used to predict the material basis and potential mechanism of Citrus peel in the treatment of type 2 diabetes by network pharmacology, and verified the results by molecular docking. Results: The α-glucosidase was inhibited by 13 kinds of Citrus peel and showed a dose-effect relationship in the linear range. It was predicted that the active ingredients naringin, tangeretin and lauric acid might inhibit hyperglycemia through oxidative stress by network pharmacology and molecular docking. Citrus peel treatment of type Ⅱ diabetes was related to PI3K-Akt, Ras, HIF-1 signaling pathway in inflammation and vascular related VEGF signaling pathway. Tangeretin was the main component. Conclusion: Citrus peel had an inhibitory effect on α-glycosidase , which might play a role in the prevention of type 2 diabetes. |
| first_indexed | 2024-03-07T21:30:11Z |
| format | Article |
| id | doaj.art-ce44b289b7f34685807703a0e672a142 |
| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-03-07T21:30:11Z |
| publishDate | 2024-03-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-ce44b289b7f34685807703a0e672a1422024-02-27T00:57:58ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062024-03-0145531933010.13386/j.issn1002-0306.20230101582023010158-5Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork AnalysisYan ZHANG0Ping YAN1Hua ZHANG2Han ZHANG3Mengdi ZHENG4Xiyan CHAI5Xi’an Medical University, Xi’an 710021, ChinaXi’an Medical University, Xi’an 710021, ChinaXi’an Medical University, Xi’an 710021, ChinaXi’an Medical University, Xi’an 710021, ChinaXi’an Medical University, Xi’an 710021, ChinaXi'an Yurun Baide Health Management Co., Ltd., Xi’an 710065, ChinaObjective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro. It were used to predict the material basis and potential mechanism of Citrus peel in the treatment of type 2 diabetes by network pharmacology, and verified the results by molecular docking. Results: The α-glucosidase was inhibited by 13 kinds of Citrus peel and showed a dose-effect relationship in the linear range. It was predicted that the active ingredients naringin, tangeretin and lauric acid might inhibit hyperglycemia through oxidative stress by network pharmacology and molecular docking. Citrus peel treatment of type Ⅱ diabetes was related to PI3K-Akt, Ras, HIF-1 signaling pathway in inflammation and vascular related VEGF signaling pathway. Tangeretin was the main component. Conclusion: Citrus peel had an inhibitory effect on α-glycosidase , which might play a role in the prevention of type 2 diabetes.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023010158citrus peelenzyme inhibitionnetwork pharmacologyhypoglycemic effect |
| spellingShingle | Yan ZHANG Ping YAN Hua ZHANG Han ZHANG Mengdi ZHENG Xiyan CHAI Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis Shipin gongye ke-ji citrus peel enzyme inhibition network pharmacology hypoglycemic effect |
| title | Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis |
| title_full | Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis |
| title_fullStr | Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis |
| title_full_unstemmed | Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis |
| title_short | Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis |
| title_sort | adjuvant prevention of type 2 diabetes of citrus peel based on bionetwork analysis |
| topic | citrus peel enzyme inhibition network pharmacology hypoglycemic effect |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2023010158 |
| work_keys_str_mv | AT yanzhang adjuvantpreventionoftype2diabetesofcitruspeelbasedonbionetworkanalysis AT pingyan adjuvantpreventionoftype2diabetesofcitruspeelbasedonbionetworkanalysis AT huazhang adjuvantpreventionoftype2diabetesofcitruspeelbasedonbionetworkanalysis AT hanzhang adjuvantpreventionoftype2diabetesofcitruspeelbasedonbionetworkanalysis AT mengdizheng adjuvantpreventionoftype2diabetesofcitruspeelbasedonbionetworkanalysis AT xiyanchai adjuvantpreventionoftype2diabetesofcitruspeelbasedonbionetworkanalysis |