PGC-1α–mediated angiogenesis prevents pulmonary hypertension in mice

PGC-1α–mediated angiogenesis prevents pulmonary hypertension in mice

Pulmonary hypertension (PH) is a life-threatening disease characterized by a progressive narrowing of pulmonary arterioles. Although VEGF is highly expressed in lung of patients with PH and in animal PH models, the involvement of angiogenesis remains elusive. To clarify the pathophysiological functi...

Full description

Bibliographic Details
Main Authors: Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Satoshi Ishii, Genri Numata, Hiroyuki Tokiwa, Manami Katoh, Sonoko Maemura, Takaaki Suzuki, Hiroshi Takiguchi, Tomonobu Yanase, Yoshiaki Kubota, Seitaro Nomura, Masaru Hatano, Kazutaka Ueda, Mutsuo Harada, Haruhiro Toko, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Satoshi Nishimura, Issei Komuro
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-09-01
Series:JCI Insight
Subjects:
Angiogenesis
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.162632

Internet

https://doi.org/10.1172/jci.insight.162632

Similar Items