Clade-Specific Virulence Patterns of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice

Clade-Specific Virulence Patterns of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice

ABSTRACT In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human primary macrophages and in mice infected by the aerosol route, both reflecting relevant model systems. Exclusively human-adapted M....

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Bibliographic Details
Main Authors: Norbert Reiling, Susanne Homolka, Kerstin Walter, Julius Brandenburg, Lisa Niwinski, Martin Ernst, Christian Herzmann, Christoph Lange, Roland Diel, Stefan Ehlers, Stefan Niemann
Format: Article
Language:English
Published: American Society for Microbiology 2013-08-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00250-13

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