Physiologically Relevant In Vitro-In Vivo Correlation (IVIVC) Approach for Sildenafil with Site-Dependent Dissolution

Physiologically Relevant In Vitro-In Vivo Correlation (IVIVC) Approach for Sildenafil with Site-Dependent Dissolution

This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling. An immediate release (IR, 20 mg) and three sustained release (SR, 60 mg) sildenafil...

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Bibliographic Details
Main Authors: Tae Hwan Kim, Soyoung Shin, Seok Won Jeong, Jong Bong Lee, Beom Soo Shin
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
sildenafil
in vitro-in vivo correlation
site-dependent dissolution
pharmacokinetics
population pharmacokinetic modeling
Online Access:https://www.mdpi.com/1999-4923/11/6/251

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https://www.mdpi.com/1999-4923/11/6/251

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