PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL
Objective: To review the correlation between prostate specific antigen (PSA) and Gleason score and Cav-1 for diagnosing prostate adenocarcinoma. Methods: Data were collected from one hundred fifty-nine patients with prostate adenocarcinoma at the Department of Urology, Dr. Hasan Sadikin General...
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| Format: | Article |
| Language: | English |
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Universitas Padjadjaran
2016-03-01
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| Series: | International Journal of Integrated Health Sciences |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/679/660 |
| _version_ | 1818096749537918976 |
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| author | Azela Glady Endah Hamidah Rahmat Budi Prasetyo Agung Budi Sutiono |
| author_facet | Azela Glady Endah Hamidah Rahmat Budi Prasetyo Agung Budi Sutiono |
| author_sort | Azela Glady |
| collection | DOAJ |
| description | Objective: To review the correlation between prostate specific antigen (PSA) and Gleason score and Cav-1 for diagnosing prostate adenocarcinoma.
Methods: Data were collected from one hundred fifty-nine patients with prostate adenocarcinoma at the Department of Urology, Dr. Hasan Sadikin General Hospital in the period of January 2008–December 2010. The PSA levels were measured and classified into <4 ng/ml, 4–10 ng/ml, and >10 ng/ml. The results were then analyzed and compared to the imunohistochemistry (caveolin-1) staining in the literature. The Gleason score was also noted and analyzed.
Results: This study confirmed that positive caveolin-1 expression was related to the clinical markers of disease progression and was predictive of poor clinical outcome after surgery. The PSA results showed that one hundred fourty-one adenocarcinoma patients had a PSA level of >10 ng/ml with Gleason score of gleason 5–6 as the most common score. However, there was no correlation between PSA and Gleason score and caveolin-1 for diagnosing prostate adenocarcinoma.
Conclusions: Caveolin-1 cannot be used to measure Gleason and PSA score due to different markers that have various advantages and disadvantages to predict carcinoma prostate. Therefore, further studies are needed. |
| first_indexed | 2024-12-10T23:09:34Z |
| format | Article |
| id | doaj.art-ce4c72ac409545c9ab2e3e0603224cd3 |
| institution | Directory Open Access Journal |
| issn | 2302-1381 2338-4506 |
| language | English |
| last_indexed | 2024-12-10T23:09:34Z |
| publishDate | 2016-03-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | International Journal of Integrated Health Sciences |
| spelling | doaj.art-ce4c72ac409545c9ab2e3e0603224cd32022-12-22T01:29:59ZengUniversitas PadjadjaranInternational Journal of Integrated Health Sciences2302-13812338-45062016-03-01411710.15850/ijihs.v4n1.679PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITALAzela Glady0Endah Hamidah1Rahmat Budi Prasetyo2Agung Budi Sutiono3Faculty of Medicine, University of Jenderal Achmad YaniFaculty of Medicine, University of Jenderal Achmad YaniFaculty of Medicine, University of Jenderal Achmad YaniDepartment of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General HospitalObjective: To review the correlation between prostate specific antigen (PSA) and Gleason score and Cav-1 for diagnosing prostate adenocarcinoma. Methods: Data were collected from one hundred fifty-nine patients with prostate adenocarcinoma at the Department of Urology, Dr. Hasan Sadikin General Hospital in the period of January 2008–December 2010. The PSA levels were measured and classified into <4 ng/ml, 4–10 ng/ml, and >10 ng/ml. The results were then analyzed and compared to the imunohistochemistry (caveolin-1) staining in the literature. The Gleason score was also noted and analyzed. Results: This study confirmed that positive caveolin-1 expression was related to the clinical markers of disease progression and was predictive of poor clinical outcome after surgery. The PSA results showed that one hundred fourty-one adenocarcinoma patients had a PSA level of >10 ng/ml with Gleason score of gleason 5–6 as the most common score. However, there was no correlation between PSA and Gleason score and caveolin-1 for diagnosing prostate adenocarcinoma. Conclusions: Caveolin-1 cannot be used to measure Gleason and PSA score due to different markers that have various advantages and disadvantages to predict carcinoma prostate. Therefore, further studies are needed.http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/679/660Gleason scoreimunohistochemistryprostate adenocarcinomaprostate specific antigen |
| spellingShingle | Azela Glady Endah Hamidah Rahmat Budi Prasetyo Agung Budi Sutiono PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL International Journal of Integrated Health Sciences Gleason score imunohistochemistry prostate adenocarcinoma prostate specific antigen |
| title | PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL |
| title_full | PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL |
| title_fullStr | PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL |
| title_full_unstemmed | PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL |
| title_short | PATTERN OF PROSTATE SPECIFIC ANTIGEN AND GLEASON SCORE IN RELATION TO IMUNOHISTOCHEMISTRY FEATURES IN PROSTATE ADENOCARCINOMA PATIENTS IN DR. HASAN SADIKIN GENERAL HOSPITAL |
| title_sort | pattern of prostate specific antigen and gleason score in relation to imunohistochemistry features in prostate adenocarcinoma patients in dr hasan sadikin general hospital |
| topic | Gleason score imunohistochemistry prostate adenocarcinoma prostate specific antigen |
| url | http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/679/660 |
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