Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer
BackgroundThermal ablation is the primary procedure for the local treatment of lung metastases. It is known that radiotherapy and cryoablation can stimulate an abscopal effect, while the occurrence of abscopal effect induced by microwave ablation is less; the cellular and molecular mechanisms involv...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1174713/full |
| _version_ | 1797838603519262720 |
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| author | Lu Yu Hairong Xie Linping Wang Min Cheng Jie Liu Jie Liu Jiamei Xu Zhigang Wei Xin Ye Qi Xie Jing Liang |
| author_facet | Lu Yu Hairong Xie Linping Wang Min Cheng Jie Liu Jie Liu Jiamei Xu Zhigang Wei Xin Ye Qi Xie Jing Liang |
| author_sort | Lu Yu |
| collection | DOAJ |
| description | BackgroundThermal ablation is the primary procedure for the local treatment of lung metastases. It is known that radiotherapy and cryoablation can stimulate an abscopal effect, while the occurrence of abscopal effect induced by microwave ablation is less; the cellular and molecular mechanisms involved in the abscopal effect after microwave ablation should be further elucidated.MethodsCT26 tumor-bearing Balb/c mice were treated with microwave ablation with several combinations of ablation power and time duration. The growth of primary or abscopal tumors and the survival of mice were both monitored; moreover, immune profiles in abscopal tumors, spleens, and lymph nodes were examined by flow cytometry.ResultsMicrowave ablation suppressed tumor growth in both primary and abscopal tumors. Both local and systemic T-cell responses were induced by microwave ablation. Furthermore, the mice exhibiting significant abscopal effect after microwave ablation markedly elevated Th1 cell proportion both in the abscopal tumors and spleens.ConclusionsMicrowave ablation at 3 w–3 min not only suppressed tumor growth in the primary tumors but also stimulated an abscopal effect in the CT26-bearing mice via the improvement of systemic and intratumoral antitumor immunity. |
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| language | English |
| last_indexed | 2024-04-09T15:43:30Z |
| publishDate | 2023-04-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-ce4d7bf7dc134d269c5add3c68dd37242023-04-27T05:33:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-04-011310.3389/fonc.2023.11747131174713Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancerLu Yu0Hairong Xie1Linping Wang2Min Cheng3Jie Liu4Jie Liu5Jiamei Xu6Zhigang Wei7Xin Ye8Qi Xie9Jing Liang10Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaDepartment of Oncology, Feicheng People’s Hospital, Feicheng, ChinaDepartment of Gerontology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaSchool of Clinical Medicine, Weifang Medical University, Weifang, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, ChinaBackgroundThermal ablation is the primary procedure for the local treatment of lung metastases. It is known that radiotherapy and cryoablation can stimulate an abscopal effect, while the occurrence of abscopal effect induced by microwave ablation is less; the cellular and molecular mechanisms involved in the abscopal effect after microwave ablation should be further elucidated.MethodsCT26 tumor-bearing Balb/c mice were treated with microwave ablation with several combinations of ablation power and time duration. The growth of primary or abscopal tumors and the survival of mice were both monitored; moreover, immune profiles in abscopal tumors, spleens, and lymph nodes were examined by flow cytometry.ResultsMicrowave ablation suppressed tumor growth in both primary and abscopal tumors. Both local and systemic T-cell responses were induced by microwave ablation. Furthermore, the mice exhibiting significant abscopal effect after microwave ablation markedly elevated Th1 cell proportion both in the abscopal tumors and spleens.ConclusionsMicrowave ablation at 3 w–3 min not only suppressed tumor growth in the primary tumors but also stimulated an abscopal effect in the CT26-bearing mice via the improvement of systemic and intratumoral antitumor immunity.https://www.frontiersin.org/articles/10.3389/fonc.2023.1174713/fullmicrowave ablationabscopal effectcolorectal cancerimmune microenvironmentT cells |
| spellingShingle | Lu Yu Hairong Xie Linping Wang Min Cheng Jie Liu Jie Liu Jiamei Xu Zhigang Wei Xin Ye Qi Xie Jing Liang Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer Frontiers in Oncology microwave ablation abscopal effect colorectal cancer immune microenvironment T cells |
| title | Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer |
| title_full | Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer |
| title_fullStr | Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer |
| title_full_unstemmed | Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer |
| title_short | Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer |
| title_sort | microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer |
| topic | microwave ablation abscopal effect colorectal cancer immune microenvironment T cells |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1174713/full |
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