Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex
trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. He...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/22/12/1868 |
| _version_ | 1819236200231206912 |
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| author | Munkhtugs Davaatseren Yeon-Ji Jo Geun-Pyo Hong Haeng Jeon Hur Sujin Park Mi-Jung Choi |
| author_facet | Munkhtugs Davaatseren Yeon-Ji Jo Geun-Pyo Hong Haeng Jeon Hur Sujin Park Mi-Jung Choi |
| author_sort | Munkhtugs Davaatseren |
| collection | DOAJ |
| description | trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone. |
| first_indexed | 2024-12-23T13:00:39Z |
| format | Article |
| id | doaj.art-ce4fded934a04a89ade49750265dd9dd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T13:00:39Z |
| publishDate | 2017-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ce4fded934a04a89ade49750265dd9dd2022-12-21T17:46:03ZengMDPI AGMolecules1420-30492017-12-012212186810.3390/molecules22121868molecules22121868Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin ComplexMunkhtugs Davaatseren0Yeon-Ji Jo1Geun-Pyo Hong2Haeng Jeon Hur3Sujin Park4Mi-Jung Choi5Department of Food Science and Technology, Chung-ang University, Gyeonggi-do 17546, KoreaInstitute of Process Engineering in Life Science, Section I: Food Process Engineering, Karlsruhe Institute of Technology, 76131 Karlsruhe, GermanyDepartment of Food Science and Biotechnology, Sejong University, 209 Neungdong-ro, Seoul 05006, KoreaDivision of Metabolism and Functionality Research, Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13539, KoreaDivision of Metabolism and Functionality Research, Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13539, KoreaDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, 120 Neungdong-ro, Seoul 05029, Koreatrans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.https://www.mdpi.com/1420-3049/22/12/1868trans-cinnamaldehydeβ-cyclodextrinself-inclusionanti-inflammationantioxidant |
| spellingShingle | Munkhtugs Davaatseren Yeon-Ji Jo Geun-Pyo Hong Haeng Jeon Hur Sujin Park Mi-Jung Choi Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex Molecules trans-cinnamaldehyde β-cyclodextrin self-inclusion anti-inflammation antioxidant |
| title | Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex |
| title_full | Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex |
| title_fullStr | Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex |
| title_full_unstemmed | Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex |
| title_short | Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex |
| title_sort | studies on the anti oxidative function of trans cinnamaldehyde included β cyclodextrin complex |
| topic | trans-cinnamaldehyde β-cyclodextrin self-inclusion anti-inflammation antioxidant |
| url | https://www.mdpi.com/1420-3049/22/12/1868 |
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