Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model

Anxiety affects the life quality of a significant percentage of autism patients. To understand the possible biological basis of this high anxiety level, we used a valproic acid (VPA) model of autism. Anxiety level is significantly higher in VPA-injected mice, at both P35 and P70. In addition, protei...

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Bibliographic Details
Main Authors: Xiaoli Gao, Rui Zheng, Xiaoyan Ma, Zhiting Gong, Dan Xia, Qiang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism
valproic acid
protein kinase Mζ
anxiety
basolateral amygdala
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00291/full

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