A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer
Five-FU is a potent chemotherapeutic agent for suppressing endothelial cell growth. The purpose of this study was to investigate the usefulness of local peritumor injection of 5-FU for patients with advanced gastric cancer (AGC) for the prevention of anemia. Between January 2020 and January 2022, pa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2022-12-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5878&vmd=Full |
| _version_ | 1827324618254319616 |
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| author | Nam-Hee Kim Jung Ho Park Dong-Hoe Koo Yoon Suk Jung Hee-Young Lee |
| author_facet | Nam-Hee Kim Jung Ho Park Dong-Hoe Koo Yoon Suk Jung Hee-Young Lee |
| author_sort | Nam-Hee Kim |
| collection | DOAJ |
| description | Five-FU is a potent chemotherapeutic agent for suppressing endothelial cell growth. The purpose of this study was to investigate the usefulness of local peritumor injection of 5-FU for patients with advanced gastric cancer (AGC) for the prevention of anemia. Between January 2020 and January 2022, patients aged 18 years or older with AGC and moderate anemia were included. A total of 200 mg of 5-FU was injected per session at ten points of the lesion (20 mg at each point) every 7 days for 4 to 12 weeks. Patients received a blood test for toxicity at every cycle. From one of these patients, endoscopic biopsy specimens were taken from gastric cancer before and after injecting 5-FU for immunostaining. A total of five AGC patients participated in this study. For most patients, hemoglobin levels were maintained without transfusions during 5-FU injection, and expression levels of thrombospondin-1 was increased after injection compared to those before injection. Blood test results during 5-FU injection showed no significant change in serum glutamic oxalacetic transaminase/glutamic pyruvic transaminase, total bilirubin, or creatinine level. The results of this study showed the possibility of local peritumor 5-FU injection as a treatment for relieving anemia of patients with gastric cancer. |
| first_indexed | 2024-03-07T13:58:30Z |
| format | Article |
| id | doaj.art-ce55615822744c71965cf2bccd0160ce |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-03-07T13:58:30Z |
| publishDate | 2022-12-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-ce55615822744c71965cf2bccd0160ce2024-03-07T06:29:22ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692022-12-0180`627328010.4166/kjg.2022.099A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric CancerNam-Hee Kim0Jung Ho Park1https://orcid.org/0000-0002-8367-4371Dong-Hoe Koo2https://orcid.org/0000-0001-9913-8883Yoon Suk Jung3Hee-Young Lee4Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, KoreaDepartment of Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, KoreaDepartment of Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, KoreaFive-FU is a potent chemotherapeutic agent for suppressing endothelial cell growth. The purpose of this study was to investigate the usefulness of local peritumor injection of 5-FU for patients with advanced gastric cancer (AGC) for the prevention of anemia. Between January 2020 and January 2022, patients aged 18 years or older with AGC and moderate anemia were included. A total of 200 mg of 5-FU was injected per session at ten points of the lesion (20 mg at each point) every 7 days for 4 to 12 weeks. Patients received a blood test for toxicity at every cycle. From one of these patients, endoscopic biopsy specimens were taken from gastric cancer before and after injecting 5-FU for immunostaining. A total of five AGC patients participated in this study. For most patients, hemoglobin levels were maintained without transfusions during 5-FU injection, and expression levels of thrombospondin-1 was increased after injection compared to those before injection. Blood test results during 5-FU injection showed no significant change in serum glutamic oxalacetic transaminase/glutamic pyruvic transaminase, total bilirubin, or creatinine level. The results of this study showed the possibility of local peritumor 5-FU injection as a treatment for relieving anemia of patients with gastric cancer.https://www.kjg.or.kr/journal/view.html?uid=5878&vmd=Fullstomach neoplasmsfluorouracilanemiaendoscopythrombospondin 1 |
| spellingShingle | Nam-Hee Kim Jung Ho Park Dong-Hoe Koo Yoon Suk Jung Hee-Young Lee A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer The Korean Journal of Gastroenterology stomach neoplasms fluorouracil anemia endoscopy thrombospondin 1 |
| title | A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer |
| title_full | A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer |
| title_fullStr | A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer |
| title_full_unstemmed | A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer |
| title_short | A Pilot Study of Peritumor Administration of 5-FU for Preventing Bleeding in Advanced Gastric Cancer |
| title_sort | pilot study of peritumor administration of 5 fu for preventing bleeding in advanced gastric cancer |
| topic | stomach neoplasms fluorouracil anemia endoscopy thrombospondin 1 |
| url | https://www.kjg.or.kr/journal/view.html?uid=5878&vmd=Full |
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