Therapeutic Effect of Argatroban During Cardiopulmonary Resuscitation and Streptokinase During Extracorporeal Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest

OBJECTIVE:. Prolonged cardiac arrest (CA) causes microvascular thrombosis which is a potential barrier to organ reperfusion during extracorporeal cardiopulmonary resuscitation (ECPR). The aim of this study was to test the hypothesis that early intra-arrest anticoagulation during cardiopulmonary resu...

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Main Authors: Jensyn J. VanZalen, MS, Stephen Harvey, BS, Pavel Hála, MD, PhD, Annie Phillips, BS, Takahiro Nakashima, MD, PhD, Emre Gok, MD, Mohamad Hakam Tiba, MD, PhD, Brendan M. McCracken, MS, Joseph E. Hill, MS, Jinhui Liao, PhD, Joshua Jung, MS, Joshua Mergos, MS, CNIM, William C. Stacey, MD, PhD, Robert H. Bartlett, MD, Cindy H. Hsu, MD, PhD, Alvaro Rojas-Peña, MD, Robert W. Neumar, MD, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2023-05-01
Series:Critical Care Explorations
Online Access:http://journals.lww.com/10.1097/CCE.0000000000000902