Profluorescent substrates for the screening of olefin metathesis catalysts
Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The resu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2015-10-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.11.203 |
| _version_ | 1818556676577427456 |
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| author | Raphael Reuter Thomas R. Ward |
| author_facet | Raphael Reuter Thomas R. Ward |
| author_sort | Raphael Reuter |
| collection | DOAJ |
| description | Herein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach. |
| first_indexed | 2024-12-13T23:50:20Z |
| format | Article |
| id | doaj.art-ce55d0041daf4ea7aebc026fb703817f |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-13T23:50:20Z |
| publishDate | 2015-10-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-ce55d0041daf4ea7aebc026fb703817f2022-12-21T23:26:47ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-10-011111886189210.3762/bjoc.11.2031860-5397-11-203Profluorescent substrates for the screening of olefin metathesis catalystsRaphael Reuter0Thomas R. Ward1Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, SwitzerlandDepartment of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, SwitzerlandHerein we report on a 96-well plate assay based on the fluorescence resulting from the ring-closing metathesis of two profluorophoric substrates. To demonstrate the validity of the approach, four commercially available ruthenium-metathesis catalysts were evaluated in six different solvents. The results from the fluorescent assay agree well with HPLC conversions, validating the usefulness of the approach.https://doi.org/10.3762/bjoc.11.203fluorescencemicroplate screeningring closing metathesis |
| spellingShingle | Raphael Reuter Thomas R. Ward Profluorescent substrates for the screening of olefin metathesis catalysts Beilstein Journal of Organic Chemistry fluorescence microplate screening ring closing metathesis |
| title | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_full | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_fullStr | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_full_unstemmed | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_short | Profluorescent substrates for the screening of olefin metathesis catalysts |
| title_sort | profluorescent substrates for the screening of olefin metathesis catalysts |
| topic | fluorescence microplate screening ring closing metathesis |
| url | https://doi.org/10.3762/bjoc.11.203 |
| work_keys_str_mv | AT raphaelreuter profluorescentsubstratesforthescreeningofolefinmetathesiscatalysts AT thomasrward profluorescentsubstratesforthescreeningofolefinmetathesiscatalysts |