Imaging characteristics of cardiac metastases in patients with malignant melanoma
Abstract Background Due to prolonged survival and technical advances in CT imaging, cardiac metastases in patients with malignant melanoma are observed more frequently nowadays. The aim of the present study was to assess the anatomic distribution as well as the morphologic and histologic appearance...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Cancer Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s40644-017-0122-8 |
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| author | Tanja Zitzelsberger Thomas K. Eigentler Patrick Krumm Konstantin Nikolaou Claus Garbe Meinrad Gawaz Bernhard Klumpp |
| author_facet | Tanja Zitzelsberger Thomas K. Eigentler Patrick Krumm Konstantin Nikolaou Claus Garbe Meinrad Gawaz Bernhard Klumpp |
| author_sort | Tanja Zitzelsberger |
| collection | DOAJ |
| description | Abstract Background Due to prolonged survival and technical advances in CT imaging, cardiac metastases in patients with malignant melanoma are observed more frequently nowadays. The aim of the present study was to assess the anatomic distribution as well as the morphologic and histologic appearance of cardiac metastases from malignant melanoma. Methods Twenty five patients with known metastasized melanoma and with incidental finding of cardiac metastases during routine staging CT were retrospectively included in this study. CT images were assessed for the presence, localization and extent of cardiac metastases. Histological results, mutational analysis and tumor markers were reviewed. Results Fourteen out of 25 patients presented with singular cardiac mass (56%), whereas ten patients (40%) presented with multifocal and one patient with disseminated cardiac metastases. Twelve patients presented with endocardial (48%), eight with myocardial and two with pericardial metastases. Most frequent site involved in endocardial metastases was the right atrium (67%) followed by the right ventricle (33%). There seems to be a correlation between histological subtype and location of cardiac metastasis. Median survival after diagnosis of cardiac metastases was 8 months, with no significant difference regarding the localization of metastases within the heart. Conclusion Cardiac metastases can involve every part of the heart possibly in dependence of histological subtype. The awareness of different types of cardiac metastases and their characteristic appearance on CT images is necessary for further investigations and might contribute to targeted therapy. |
| first_indexed | 2024-12-17T20:29:17Z |
| format | Article |
| id | doaj.art-ce56c48237064b3ab82cd8ad736ae9ba |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-17T20:29:17Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-ce56c48237064b3ab82cd8ad736ae9ba2022-12-21T21:33:38ZengBMCCancer Imaging1470-73302017-07-011711810.1186/s40644-017-0122-8Imaging characteristics of cardiac metastases in patients with malignant melanomaTanja Zitzelsberger0Thomas K. Eigentler1Patrick Krumm2Konstantin Nikolaou3Claus Garbe4Meinrad Gawaz5Bernhard Klumpp6Department of Diagnostic and Interventional Radiology, Eberhard Karls University TuebingenEberhard-Karls-University Tuebingen, Center for DermatooncologyDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University TuebingenDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University TuebingenEberhard-Karls-University Tuebingen, Center for DermatooncologyDepartment of Cardiology, Eberhard Karls University TuebingenDepartment of Diagnostic and Interventional Radiology, Eberhard Karls University TuebingenAbstract Background Due to prolonged survival and technical advances in CT imaging, cardiac metastases in patients with malignant melanoma are observed more frequently nowadays. The aim of the present study was to assess the anatomic distribution as well as the morphologic and histologic appearance of cardiac metastases from malignant melanoma. Methods Twenty five patients with known metastasized melanoma and with incidental finding of cardiac metastases during routine staging CT were retrospectively included in this study. CT images were assessed for the presence, localization and extent of cardiac metastases. Histological results, mutational analysis and tumor markers were reviewed. Results Fourteen out of 25 patients presented with singular cardiac mass (56%), whereas ten patients (40%) presented with multifocal and one patient with disseminated cardiac metastases. Twelve patients presented with endocardial (48%), eight with myocardial and two with pericardial metastases. Most frequent site involved in endocardial metastases was the right atrium (67%) followed by the right ventricle (33%). There seems to be a correlation between histological subtype and location of cardiac metastasis. Median survival after diagnosis of cardiac metastases was 8 months, with no significant difference regarding the localization of metastases within the heart. Conclusion Cardiac metastases can involve every part of the heart possibly in dependence of histological subtype. The awareness of different types of cardiac metastases and their characteristic appearance on CT images is necessary for further investigations and might contribute to targeted therapy.http://link.springer.com/article/10.1186/s40644-017-0122-8Malignant melanomaMetastasisHeart |
| spellingShingle | Tanja Zitzelsberger Thomas K. Eigentler Patrick Krumm Konstantin Nikolaou Claus Garbe Meinrad Gawaz Bernhard Klumpp Imaging characteristics of cardiac metastases in patients with malignant melanoma Cancer Imaging Malignant melanoma Metastasis Heart |
| title | Imaging characteristics of cardiac metastases in patients with malignant melanoma |
| title_full | Imaging characteristics of cardiac metastases in patients with malignant melanoma |
| title_fullStr | Imaging characteristics of cardiac metastases in patients with malignant melanoma |
| title_full_unstemmed | Imaging characteristics of cardiac metastases in patients with malignant melanoma |
| title_short | Imaging characteristics of cardiac metastases in patients with malignant melanoma |
| title_sort | imaging characteristics of cardiac metastases in patients with malignant melanoma |
| topic | Malignant melanoma Metastasis Heart |
| url | http://link.springer.com/article/10.1186/s40644-017-0122-8 |
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