Osteomodulin downregulation is associated with osteoarthritis development

Osteomodulin downregulation is associated with osteoarthritis development

Abstract Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, spe...

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Bibliographic Details
Main Authors: Jérémie Zappia, Qiao Tong, Renée Van der Cruyssen, Frederique M. F. Cornelis, Cécile Lambert, Tiago Pinto Coelho, Juliane Grisart, Erika Kague, Rik J. Lories, Marc Muller, Dirk Elewaut, Chrissy L. Hammond, Christelle Sanchez, Yves Henrotin
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00286-5

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