Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
Five new eunicellin-based diterpenoids, krempfielins E–I (1–5) and seven known compounds (6–12) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-03-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/11/3/788 |
| _version_ | 1798041685185265664 |
|---|---|
| author | Jyh-Horng Sheu Zhi-Hong Wen Chang-Feng Dai Ming-Shyan Huang Chiung-Yao Huang Chi-Jen Tai Jui-Hsin Su |
| author_facet | Jyh-Horng Sheu Zhi-Hong Wen Chang-Feng Dai Ming-Shyan Huang Chiung-Yao Huang Chi-Jen Tai Jui-Hsin Su |
| author_sort | Jyh-Horng Sheu |
| collection | DOAJ |
| description | Five new eunicellin-based diterpenoids, krempfielins E–I (1–5) and seven known compounds (6–12) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells. |
| first_indexed | 2024-04-11T22:25:01Z |
| format | Article |
| id | doaj.art-ce58b55baa244cec986dc5b5e14b6737 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:25:01Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ce58b55baa244cec986dc5b5e14b67372022-12-22T03:59:49ZengMDPI AGMarine Drugs1660-33972013-03-0111378879910.3390/md11030788Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfiJyh-Horng SheuZhi-Hong WenChang-Feng DaiMing-Shyan HuangChiung-Yao HuangChi-Jen TaiJui-Hsin SuFive new eunicellin-based diterpenoids, krempfielins E–I (1–5) and seven known compounds (6–12) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.http://www.mdpi.com/1660-3397/11/3/788eunicellin-based diterpenoidsCladiella krempficytotoxicityanti-inflammatory agents |
| spellingShingle | Jyh-Horng Sheu Zhi-Hong Wen Chang-Feng Dai Ming-Shyan Huang Chiung-Yao Huang Chi-Jen Tai Jui-Hsin Su Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi Marine Drugs eunicellin-based diterpenoids Cladiella krempfi cytotoxicity anti-inflammatory agents |
| title | Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi |
| title_full | Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi |
| title_fullStr | Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi |
| title_full_unstemmed | Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi |
| title_short | Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi |
| title_sort | cytotoxic and anti inflammatory eunicellin based diterpenoids from the soft coral cladiella krempfi |
| topic | eunicellin-based diterpenoids Cladiella krempfi cytotoxicity anti-inflammatory agents |
| url | http://www.mdpi.com/1660-3397/11/3/788 |
| work_keys_str_mv | AT jyhhorngsheu cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi AT zhihongwen cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi AT changfengdai cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi AT mingshyanhuang cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi AT chiungyaohuang cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi AT chijentai cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi AT juihsinsu cytotoxicandantiinflammatoryeunicellinbasedditerpenoidsfromthesoftcoralcladiellakrempfi |