Suppression of SREBP-1 Expression by Simvastatin Decreases Visfatin-Induced Chemoresistance to Sunitinib in Human Renal Carcinoma 786-O Cells

Suppression of SREBP-1 Expression by Simvastatin Decreases Visfatin-Induced Chemoresistance to Sunitinib in Human Renal Carcinoma 786-O Cells

The resistance of renal cell carcinoma (RCC) to sunitinib impedes the success of chemotherapy in cancer treatment. Although several sunitinib resistance mechanisms have been proposed, little is known concerning the impact of obesity and adipokines in RCC cells. The upregulation of sterol-regulatory...

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Bibliographic Details
Main Authors: Te-Chuan Chen, Chen-Wei Huang, Chih-Yu Lo, Cheng-Nan Chen, Shun-Fu Chang, Yih-Yuan Chen
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Life
Subjects:
renal cell carcinoma
sunitinib
SREBP-1
visfatin
simvastatin
Online Access:https://www.mdpi.com/2075-1729/12/11/1890

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