Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis
Alzheimer’s disease (AD) has become one of the leading causes of health problems in the elderly, and studying its causes and treatments remains a serious challenge for researchers worldwide. The two main pathological features of Alzheimer’s disease are the extracellular deposition of β-amyloid (Aβ)...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/11/2203 |
| _version_ | 1797458671616131072 |
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| author | Dan Tang Chang Sun Jumei Yang Lili Fan Yonggang Wang |
| author_facet | Dan Tang Chang Sun Jumei Yang Lili Fan Yonggang Wang |
| author_sort | Dan Tang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) has become one of the leading causes of health problems in the elderly, and studying its causes and treatments remains a serious challenge for researchers worldwide. The two main pathological features of Alzheimer’s disease are the extracellular deposition of β-amyloid (Aβ) to form senile plaques and the intracellular aggregation of hyperphosphorylated Tau protein to form neurofibrillary tangles (NFTs). Researchers have proposed several hypotheses to elucidate the pathogenesis of AD, but due to the complexity of the pathophysiologic factors involved in the development of AD, no effective drugs have been found to stop the progression of the disease. Currently, the mainstay drugs used to treat AD can only alleviate the patient’s symptoms and do not have a therapeutic effect. As researchers explore interactions among diseases, much evidence suggests that there is a close link between periodontitis and AD, and that periodontal pathogenic bacteria can exacerbate Aβ deposition and Tau protein hyperphosphorylation through neuroinflammatory mechanisms, thereby advancing the pathogenesis of AD. This article reviews recent advances in the pathogenesis of AD, available therapeutic agents, the relevance of periodontitis to AD, and mechanisms of action. |
| first_indexed | 2024-03-09T16:40:30Z |
| format | Article |
| id | doaj.art-ce5b8b4479f045d2a68675ac9fc8e8a2 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T16:40:30Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-ce5b8b4479f045d2a68675ac9fc8e8a22023-11-24T14:52:34ZengMDPI AGLife2075-17292023-11-011311220310.3390/life13112203Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with PeriodontitisDan Tang0Chang Sun1Jumei Yang2Lili Fan3Yonggang Wang4School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaLanzhou University Second Hospital, Lanzhou 730000, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaSchool of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, ChinaAlzheimer’s disease (AD) has become one of the leading causes of health problems in the elderly, and studying its causes and treatments remains a serious challenge for researchers worldwide. The two main pathological features of Alzheimer’s disease are the extracellular deposition of β-amyloid (Aβ) to form senile plaques and the intracellular aggregation of hyperphosphorylated Tau protein to form neurofibrillary tangles (NFTs). Researchers have proposed several hypotheses to elucidate the pathogenesis of AD, but due to the complexity of the pathophysiologic factors involved in the development of AD, no effective drugs have been found to stop the progression of the disease. Currently, the mainstay drugs used to treat AD can only alleviate the patient’s symptoms and do not have a therapeutic effect. As researchers explore interactions among diseases, much evidence suggests that there is a close link between periodontitis and AD, and that periodontal pathogenic bacteria can exacerbate Aβ deposition and Tau protein hyperphosphorylation through neuroinflammatory mechanisms, thereby advancing the pathogenesis of AD. This article reviews recent advances in the pathogenesis of AD, available therapeutic agents, the relevance of periodontitis to AD, and mechanisms of action.https://www.mdpi.com/2075-1729/13/11/2203Alzheimer’s diseasepathogenesistreatmentperiodontitis<i>Porphyromonas gingivalis</i> |
| spellingShingle | Dan Tang Chang Sun Jumei Yang Lili Fan Yonggang Wang Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis Life Alzheimer’s disease pathogenesis treatment periodontitis <i>Porphyromonas gingivalis</i> |
| title | Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis |
| title_full | Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis |
| title_fullStr | Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis |
| title_full_unstemmed | Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis |
| title_short | Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis |
| title_sort | advances in the study of the pathology and treatment of alzheimer s disease and its association with periodontitis |
| topic | Alzheimer’s disease pathogenesis treatment periodontitis <i>Porphyromonas gingivalis</i> |
| url | https://www.mdpi.com/2075-1729/13/11/2203 |
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