Endocarditis in the Mediterranean Basin
Infective endocarditis is a severe disease with high mortality. Despite a global trend towards an increase in staphylococcal aetiologies, in older patients and a decrease in viridans streptococci, we have observed in recent studies great epidemiologic disparities between countries. In order to evalu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-11-01
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| Series: | New Microbes and New Infections |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2052297518300398 |
| _version_ | 1811228522780295168 |
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| author | F. Gouriet H. Chaudet P. Gautret L. Pellegrin V.P. de Santi H. Savini G. Texier D. Raoult P.-E. Fournier |
| author_facet | F. Gouriet H. Chaudet P. Gautret L. Pellegrin V.P. de Santi H. Savini G. Texier D. Raoult P.-E. Fournier |
| author_sort | F. Gouriet |
| collection | DOAJ |
| description | Infective endocarditis is a severe disease with high mortality. Despite a global trend towards an increase in staphylococcal aetiologies, in older patients and a decrease in viridans streptococci, we have observed in recent studies great epidemiologic disparities between countries. In order to evaluate these differences among Mediterranean countries, we performed a PubMed search of infective endocarditis case series for each country. Data were available for 13 of the 18 Mediterranean countries. Despite great differences in diagnostic strategies, we could classify countries into three groups. In northern countries, patients are older (>50 years old), have a high rate of prosthetic valves or cardiac electronic implantable devices and the main causative agent is Staphylococcus aureus. In southern countries, patients are younger (<40 years old), rheumatic heart disease remains a major risk factor (45–93%), viridans streptococci are the main pathogens, zoonotic and arthropod-borne agents are frequent and blood culture–negative endocarditis remains highly prevalent. Eastern Mediterranean countries exhibit an intermediate situation: patients are 45 to 60 years old, the incidence of rheumatic heart disease ranges from 8% to 66%, viridans streptococci play a predominant role and zoonotic and arthropod-borne diseases, in particular brucellosis, are identified in up to 12% of cases. Keywords: Diagnosis, endocarditis, epidemiology, Mediterranean Sea, zoonoses |
| first_indexed | 2024-04-12T09:58:58Z |
| format | Article |
| id | doaj.art-ce5d5f74d05b41a39163fb08a199c80f |
| institution | Directory Open Access Journal |
| issn | 2052-2975 |
| language | English |
| last_indexed | 2024-04-12T09:58:58Z |
| publishDate | 2018-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj.art-ce5d5f74d05b41a39163fb08a199c80f2022-12-22T03:37:36ZengElsevierNew Microbes and New Infections2052-29752018-11-0126S43S51Endocarditis in the Mediterranean BasinF. Gouriet0H. Chaudet1P. Gautret2L. Pellegrin3V.P. de Santi4H. Savini5G. Texier6D. Raoult7P.-E. Fournier8UMR MEPHI, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, France; Forces Centre for Epidemiology and Public Health, French Forces Health Services, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, France; Forces Centre for Epidemiology and Public Health, French Forces Health Services, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, France; Military Teaching Hospital Laveran, Department of Infectious Diseases and Tropical Medicine, French Forces Health Services, Marseille, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, France; Forces Centre for Epidemiology and Public Health, French Forces Health Services, FranceUMR MEPHI, FranceUMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, France; Corresponding author: P.-E. Fournier, UMR MEPHI, Aix-Marseille Université, IRD, AP-HM, IHU Méditerranée-Infection, 19-21 Bd Jean Moulin, 13005 Marseille, France.Infective endocarditis is a severe disease with high mortality. Despite a global trend towards an increase in staphylococcal aetiologies, in older patients and a decrease in viridans streptococci, we have observed in recent studies great epidemiologic disparities between countries. In order to evaluate these differences among Mediterranean countries, we performed a PubMed search of infective endocarditis case series for each country. Data were available for 13 of the 18 Mediterranean countries. Despite great differences in diagnostic strategies, we could classify countries into three groups. In northern countries, patients are older (>50 years old), have a high rate of prosthetic valves or cardiac electronic implantable devices and the main causative agent is Staphylococcus aureus. In southern countries, patients are younger (<40 years old), rheumatic heart disease remains a major risk factor (45–93%), viridans streptococci are the main pathogens, zoonotic and arthropod-borne agents are frequent and blood culture–negative endocarditis remains highly prevalent. Eastern Mediterranean countries exhibit an intermediate situation: patients are 45 to 60 years old, the incidence of rheumatic heart disease ranges from 8% to 66%, viridans streptococci play a predominant role and zoonotic and arthropod-borne diseases, in particular brucellosis, are identified in up to 12% of cases. Keywords: Diagnosis, endocarditis, epidemiology, Mediterranean Sea, zoonoseshttp://www.sciencedirect.com/science/article/pii/S2052297518300398 |
| spellingShingle | F. Gouriet H. Chaudet P. Gautret L. Pellegrin V.P. de Santi H. Savini G. Texier D. Raoult P.-E. Fournier Endocarditis in the Mediterranean Basin New Microbes and New Infections |
| title | Endocarditis in the Mediterranean Basin |
| title_full | Endocarditis in the Mediterranean Basin |
| title_fullStr | Endocarditis in the Mediterranean Basin |
| title_full_unstemmed | Endocarditis in the Mediterranean Basin |
| title_short | Endocarditis in the Mediterranean Basin |
| title_sort | endocarditis in the mediterranean basin |
| url | http://www.sciencedirect.com/science/article/pii/S2052297518300398 |
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