MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network
microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families have been identified as key players in adipogenesis. Here, we show the relevance of the miR...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/15792 |
| _version_ | 1797457289681043456 |
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| author | Paula Juiz-Valiña Bárbara María Varela-Rodríguez Elena Outeiriño-Blanco María Jesús García-Brao Enrique Mena Fernando Cordido Susana Sangiao-Alvarellos |
| author_facet | Paula Juiz-Valiña Bárbara María Varela-Rodríguez Elena Outeiriño-Blanco María Jesús García-Brao Enrique Mena Fernando Cordido Susana Sangiao-Alvarellos |
| author_sort | Paula Juiz-Valiña |
| collection | DOAJ |
| description | microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families have been identified as key players in adipogenesis. Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. In vitro experiments identified miR-19a and b as crucial actors in adipogenesis and lipid accumulation. Overall, our results suggest a novel role of the miR-19 family in the regulatory networks underlying adipogenesis and, therefore, adipose tissue dysfunction. |
| first_indexed | 2024-03-09T16:20:04Z |
| format | Article |
| id | doaj.art-ce5deb1546134c8aa71578215f82de74 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:20:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ce5deb1546134c8aa71578215f82de742023-11-24T15:28:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241579210.3390/ijms232415792MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional NetworkPaula Juiz-Valiña0Bárbara María Varela-Rodríguez1Elena Outeiriño-Blanco2María Jesús García-Brao3Enrique Mena4Fernando Cordido5Susana Sangiao-Alvarellos6Endocrine, Nutritional and Metabolic Diseases Group, CICA—Centro Interdisciplinar de Química e Bioloxía, Universidade de A Coruña, As Carballeiras, s/n, Campus de Elviña, 15071 A Coruña, SpainEndocrine, Nutritional and Metabolic Diseases Group, CICA—Centro Interdisciplinar de Química e Bioloxía, Universidade de A Coruña, As Carballeiras, s/n, Campus de Elviña, 15071 A Coruña, SpainDepartment of Endocrinology, Hospital Universitario A Coruña, 15006 A Coruña, SpainDepartment of General Surgery, Hospital Universitario A Coruña, 15006 A Coruña, SpainDepartment of General Surgery, Hospital Universitario A Coruña, 15006 A Coruña, SpainEndocrine, Nutritional and Metabolic Diseases Group, CICA—Centro Interdisciplinar de Química e Bioloxía, Universidade de A Coruña, As Carballeiras, s/n, Campus de Elviña, 15071 A Coruña, SpainEndocrine, Nutritional and Metabolic Diseases Group, CICA—Centro Interdisciplinar de Química e Bioloxía, Universidade de A Coruña, As Carballeiras, s/n, Campus de Elviña, 15071 A Coruña, SpainmicroRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families have been identified as key players in adipogenesis. Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. In vitro experiments identified miR-19a and b as crucial actors in adipogenesis and lipid accumulation. Overall, our results suggest a novel role of the miR-19 family in the regulatory networks underlying adipogenesis and, therefore, adipose tissue dysfunction.https://www.mdpi.com/1422-0067/23/24/15792adipogenesismiR-19 familymorbid obesityadipose tissuebariatric surgeryPPARγ |
| spellingShingle | Paula Juiz-Valiña Bárbara María Varela-Rodríguez Elena Outeiriño-Blanco María Jesús García-Brao Enrique Mena Fernando Cordido Susana Sangiao-Alvarellos MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network International Journal of Molecular Sciences adipogenesis miR-19 family morbid obesity adipose tissue bariatric surgery PPARγ |
| title | MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network |
| title_full | MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network |
| title_fullStr | MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network |
| title_full_unstemmed | MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network |
| title_short | MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARγ Transcriptional Network |
| title_sort | mir 19 family impairs adipogenesis by the downregulation of the pparγ transcriptional network |
| topic | adipogenesis miR-19 family morbid obesity adipose tissue bariatric surgery PPARγ |
| url | https://www.mdpi.com/1422-0067/23/24/15792 |
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