Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants
ObjectiveTo evaluate the effects of antenatal corticosteroids (ACS) on blood glucose fluctuations in late-preterm neonates.MethodsA retrospective study was performed on 236 neonates with gestational age of 34+0 to 36+6 weeks who were admitted to the neonatology department of a tertiary general hospi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1036565/full |
| _version_ | 1811231051840749568 |
|---|---|
| author | Cailing Zhou Wanli Zheng Meixian Zhang Tao-Hsin Tung Linghua Wang Lizhen Wang |
| author_facet | Cailing Zhou Wanli Zheng Meixian Zhang Tao-Hsin Tung Linghua Wang Lizhen Wang |
| author_sort | Cailing Zhou |
| collection | DOAJ |
| description | ObjectiveTo evaluate the effects of antenatal corticosteroids (ACS) on blood glucose fluctuations in late-preterm neonates.MethodsA retrospective study was performed on 236 neonates with gestational age of 34+0 to 36+6 weeks who were admitted to the neonatology department of a tertiary general hospital in China's Zhejiang Province between April 2020 and February 2022. The neonates were divided into three groups: complete course, partial course, and control. Primary outcome was the neonatal blood glucose levels within the first 48 h of life.Results134 (56.8%) newborns were exposed to a complete course of ACS, 56 (23.7%) had a to a partial course of ACS, and 46 (19.5%) had no exposure to ACS. The patients in the complete course group had the highest proportion of neonatal hypoglycemia (16.4% vs. 3.6% and 6.5%).The patients exposed to a complete course of dexamethasone had significantly lower blood glucose levels within 12 h of birth than the control group, although no significant differences were observed after 24 h. Differences in blood glucose levels were more significant among male infants, although blood glucose curves of the male and female infants remained close to the overall trend.ConclusionsBlood glucose levels in late-preterm neonates may decrease after ACS administration, especially after exposure to a complete course. The effects are more pronounced in the first 12 h of life, with males being more severely affected; however, the effects on blood glucose levels were not significant 24 h after birth. This can provide a reference for future clinical studies. |
| first_indexed | 2024-04-12T10:38:32Z |
| format | Article |
| id | doaj.art-ce5ef423cc7c448c8c8f84406f999d4a |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T10:38:32Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ce5ef423cc7c448c8c8f84406f999d4a2022-12-22T03:36:39ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-11-011010.3389/fped.2022.10365651036565Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infantsCailing ZhouWanli ZhengMeixian ZhangTao-Hsin TungLinghua WangLizhen WangObjectiveTo evaluate the effects of antenatal corticosteroids (ACS) on blood glucose fluctuations in late-preterm neonates.MethodsA retrospective study was performed on 236 neonates with gestational age of 34+0 to 36+6 weeks who were admitted to the neonatology department of a tertiary general hospital in China's Zhejiang Province between April 2020 and February 2022. The neonates were divided into three groups: complete course, partial course, and control. Primary outcome was the neonatal blood glucose levels within the first 48 h of life.Results134 (56.8%) newborns were exposed to a complete course of ACS, 56 (23.7%) had a to a partial course of ACS, and 46 (19.5%) had no exposure to ACS. The patients in the complete course group had the highest proportion of neonatal hypoglycemia (16.4% vs. 3.6% and 6.5%).The patients exposed to a complete course of dexamethasone had significantly lower blood glucose levels within 12 h of birth than the control group, although no significant differences were observed after 24 h. Differences in blood glucose levels were more significant among male infants, although blood glucose curves of the male and female infants remained close to the overall trend.ConclusionsBlood glucose levels in late-preterm neonates may decrease after ACS administration, especially after exposure to a complete course. The effects are more pronounced in the first 12 h of life, with males being more severely affected; however, the effects on blood glucose levels were not significant 24 h after birth. This can provide a reference for future clinical studies.https://www.frontiersin.org/articles/10.3389/fped.2022.1036565/fulllate pretermdexamethasonegestational ageneonatehypoglycemia |
| spellingShingle | Cailing Zhou Wanli Zheng Meixian Zhang Tao-Hsin Tung Linghua Wang Lizhen Wang Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants Frontiers in Pediatrics late preterm dexamethasone gestational age neonate hypoglycemia |
| title | Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants |
| title_full | Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants |
| title_fullStr | Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants |
| title_full_unstemmed | Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants |
| title_short | Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants |
| title_sort | effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late preterm infants |
| topic | late preterm dexamethasone gestational age neonate hypoglycemia |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1036565/full |
| work_keys_str_mv | AT cailingzhou effectsofantenatalcorticosteroidsonneonatalbloodglucosefluctuationinlatepreterminfants AT wanlizheng effectsofantenatalcorticosteroidsonneonatalbloodglucosefluctuationinlatepreterminfants AT meixianzhang effectsofantenatalcorticosteroidsonneonatalbloodglucosefluctuationinlatepreterminfants AT taohsintung effectsofantenatalcorticosteroidsonneonatalbloodglucosefluctuationinlatepreterminfants AT linghuawang effectsofantenatalcorticosteroidsonneonatalbloodglucosefluctuationinlatepreterminfants AT lizhenwang effectsofantenatalcorticosteroidsonneonatalbloodglucosefluctuationinlatepreterminfants |