Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites
Abstract Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, to strike a balance between meeting industry demands and conserving natural habita...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Microbial Cell Factories |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12934-023-02234-8 |
| _version_ | 1797362741546057728 |
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| author | Poonam Kumari Nikky Deepa Prabodh Kumar Trivedi Brajesh K. Singh Vaibhav Srivastava Akanksha Singh |
| author_facet | Poonam Kumari Nikky Deepa Prabodh Kumar Trivedi Brajesh K. Singh Vaibhav Srivastava Akanksha Singh |
| author_sort | Poonam Kumari |
| collection | DOAJ |
| description | Abstract Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, to strike a balance between meeting industry demands and conserving natural habitats, medicinal plants are being cultivated on a large scale. However, to enhance the yield and simultaneously manage the various pest infestations, agrochemicals are being routinely used that have a detrimental impact on the whole ecosystem, ranging from biodiversity loss to water pollution, soil degradation, nutrient imbalance and enormous health hazards to both consumers and agricultural workers. To address the challenges, biological eco-friendly alternatives are being looked upon with high hopes where endophytes pitch in as key players due to their tight association with the host plants. The intricate interplay between plants and endophytic microorganisms has emerged as a captivating subject of scientific investigation, with profound implications for the sustainable biosynthesis of pharmaceutically important secondary metabolites. This review delves into the hidden world of the "secret wedlock" between plants and endophytes, elucidating their multifaceted interactions that underpin the synthesis of bioactive compounds with medicinal significance in their plant hosts. Here, we briefly review endophytic diversity association with medicinal plants and highlight the potential role of core endomicrobiome. We also propose that successful implementation of in situ microbiome manipulation through high-end techniques can pave the way towards a more sustainable and pharmaceutically enriched future. |
| first_indexed | 2024-03-08T16:11:47Z |
| format | Article |
| id | doaj.art-ce6143ae79e44d28be57941b06eed869 |
| institution | Directory Open Access Journal |
| issn | 1475-2859 |
| language | English |
| last_indexed | 2024-03-08T16:11:47Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbial Cell Factories |
| spelling | doaj.art-ce6143ae79e44d28be57941b06eed8692024-01-07T12:55:33ZengBMCMicrobial Cell Factories1475-28592023-11-0122111910.1186/s12934-023-02234-8Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolitesPoonam Kumari0Nikky Deepa1Prabodh Kumar Trivedi2Brajesh K. Singh3Vaibhav Srivastava4Akanksha Singh5Division of Crop Production and Protection, Central Institute of Medicinal and Aromatic PlantsDivision of Crop Production and Protection, Central Institute of Medicinal and Aromatic PlantsDivision of Plant Biotechnology, Central Institute of Medicinal and Aromatic PlantsHawkesbury Institute for the Environment, Western Sydney UniversityDivision of Glycoscience, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University CenterDivision of Crop Production and Protection, Central Institute of Medicinal and Aromatic PlantsAbstract Many plants possess immense pharmacological properties because of the presence of various therapeutic bioactive secondary metabolites that are of great importance in many pharmaceutical industries. Therefore, to strike a balance between meeting industry demands and conserving natural habitats, medicinal plants are being cultivated on a large scale. However, to enhance the yield and simultaneously manage the various pest infestations, agrochemicals are being routinely used that have a detrimental impact on the whole ecosystem, ranging from biodiversity loss to water pollution, soil degradation, nutrient imbalance and enormous health hazards to both consumers and agricultural workers. To address the challenges, biological eco-friendly alternatives are being looked upon with high hopes where endophytes pitch in as key players due to their tight association with the host plants. The intricate interplay between plants and endophytic microorganisms has emerged as a captivating subject of scientific investigation, with profound implications for the sustainable biosynthesis of pharmaceutically important secondary metabolites. This review delves into the hidden world of the "secret wedlock" between plants and endophytes, elucidating their multifaceted interactions that underpin the synthesis of bioactive compounds with medicinal significance in their plant hosts. Here, we briefly review endophytic diversity association with medicinal plants and highlight the potential role of core endomicrobiome. We also propose that successful implementation of in situ microbiome manipulation through high-end techniques can pave the way towards a more sustainable and pharmaceutically enriched future.https://doi.org/10.1186/s12934-023-02234-8Core endomicrobiomeEndophytesMedicinal plantsMicrobiome engineeringSecondary Metabolites |
| spellingShingle | Poonam Kumari Nikky Deepa Prabodh Kumar Trivedi Brajesh K. Singh Vaibhav Srivastava Akanksha Singh Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites Microbial Cell Factories Core endomicrobiome Endophytes Medicinal plants Microbiome engineering Secondary Metabolites |
| title | Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites |
| title_full | Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites |
| title_fullStr | Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites |
| title_full_unstemmed | Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites |
| title_short | Plants and endophytes interaction: a “secret wedlock” for sustainable biosynthesis of pharmaceutically important secondary metabolites |
| title_sort | plants and endophytes interaction a secret wedlock for sustainable biosynthesis of pharmaceutically important secondary metabolites |
| topic | Core endomicrobiome Endophytes Medicinal plants Microbiome engineering Secondary Metabolites |
| url | https://doi.org/10.1186/s12934-023-02234-8 |
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