Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties
Non-viable preparations of probiotics, as whole-cell postbiotics, attract increasing interest because of their intrinsic technological stability, and their functional properties, such as immune system modulation, gut barrier maintenance, and protection against pathogens. However, reports on <i>...
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MDPI AG
2021-03-01
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Series: | Antioxidants |
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Online Access: | https://www.mdpi.com/2076-3921/10/4/536 |
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author | Patricia Martorell Beatriz Alvarez Silvia Llopis Veronica Navarro Pepa Ortiz Nuria Gonzalez Ferrán Balaguer Antonia Rojas Empar Chenoll Daniel Ramón Marta Tortajada |
author_facet | Patricia Martorell Beatriz Alvarez Silvia Llopis Veronica Navarro Pepa Ortiz Nuria Gonzalez Ferrán Balaguer Antonia Rojas Empar Chenoll Daniel Ramón Marta Tortajada |
author_sort | Patricia Martorell |
collection | DOAJ |
description | Non-viable preparations of probiotics, as whole-cell postbiotics, attract increasing interest because of their intrinsic technological stability, and their functional properties, such as immune system modulation, gut barrier maintenance, and protection against pathogens. However, reports on <i>Bifidobacteria</i>-derived postbiotics remain scarce. This study aims to demonstrate the functional properties of a heat-treated (HT), non-viable, <i>Bifidobacterium longum</i> strain, CECT-7347, a strain previously selected for its anti-inflammatory phenotype and ability to improve biomarkers of intestinal integrity in clinical trials. The study used the nematode <i>Caenorhabditis elegans</i> and HT-29 cell cultures as eukaryotic model systems. Our results show that HT-CECT-7347 preserves the capacity to protect against oxidative stress damage, while it also reduces acute inflammatory response and gut-barrier disruption, and inhibits bacterial colonization, by activating pathways related to innate immune function. These findings highlight the interest of the ingredient as a novel postbiotic and pave the way to broaden the range of HT-CECT-7347 applications in gut health. |
first_indexed | 2024-03-10T12:47:49Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 2076-3921 |
language | English |
last_indexed | 2024-03-10T12:47:49Z |
publishDate | 2021-03-01 |
publisher | MDPI AG |
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series | Antioxidants |
spelling | doaj.art-ce61749cf5fe4a5e8bb46d688662b33d2023-11-21T13:21:38ZengMDPI AGAntioxidants2076-39212021-03-0110453610.3390/antiox10040536Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection PropertiesPatricia Martorell0Beatriz Alvarez1Silvia Llopis2Veronica Navarro3Pepa Ortiz4Nuria Gonzalez5Ferrán Balaguer6Antonia Rojas7Empar Chenoll8Daniel Ramón9Marta Tortajada10Archer Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainArcher Daniels Midland, Nutrition, Health&Wellness, Biopolis S.L. Parc Scientific Universitat de València, C/Catedrático Agustín Escardino Benlloch, 9, Paterna, 46980 Valencia, SpainNon-viable preparations of probiotics, as whole-cell postbiotics, attract increasing interest because of their intrinsic technological stability, and their functional properties, such as immune system modulation, gut barrier maintenance, and protection against pathogens. However, reports on <i>Bifidobacteria</i>-derived postbiotics remain scarce. This study aims to demonstrate the functional properties of a heat-treated (HT), non-viable, <i>Bifidobacterium longum</i> strain, CECT-7347, a strain previously selected for its anti-inflammatory phenotype and ability to improve biomarkers of intestinal integrity in clinical trials. The study used the nematode <i>Caenorhabditis elegans</i> and HT-29 cell cultures as eukaryotic model systems. Our results show that HT-CECT-7347 preserves the capacity to protect against oxidative stress damage, while it also reduces acute inflammatory response and gut-barrier disruption, and inhibits bacterial colonization, by activating pathways related to innate immune function. These findings highlight the interest of the ingredient as a novel postbiotic and pave the way to broaden the range of HT-CECT-7347 applications in gut health.https://www.mdpi.com/2076-3921/10/4/536<i>Bifidobacterium</i>postbioticprobiotic<i>Caenorhabditis elegans</i>anti-inflammatorygut-barrier |
spellingShingle | Patricia Martorell Beatriz Alvarez Silvia Llopis Veronica Navarro Pepa Ortiz Nuria Gonzalez Ferrán Balaguer Antonia Rojas Empar Chenoll Daniel Ramón Marta Tortajada Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties Antioxidants <i>Bifidobacterium</i> postbiotic probiotic <i>Caenorhabditis elegans</i> anti-inflammatory gut-barrier |
title | Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties |
title_full | Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties |
title_fullStr | Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties |
title_full_unstemmed | Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties |
title_short | Heat-Treated <i>Bifidobacterium longum</i> CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties |
title_sort | heat treated i bifidobacterium longum i cect 7347 a whole cell postbiotic with antioxidant anti inflammatory and gut barrier protection properties |
topic | <i>Bifidobacterium</i> postbiotic probiotic <i>Caenorhabditis elegans</i> anti-inflammatory gut-barrier |
url | https://www.mdpi.com/2076-3921/10/4/536 |
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