Amphiphilic Cyclodextrin Nanoparticles as Delivery System for Idebenone: A Preformulation Study

Amphiphilic Cyclodextrin Nanoparticles as Delivery System for Idebenone: A Preformulation Study

Idebenone (IDE), a synthetic short-chain analogue of coenzyme Q10, is a potent antioxidant able to prevent lipid peroxidation and stimulate nerve growth factor. Due to these properties, IDE could potentially be active towards cerebral disorders, but its poor water solubility limits its clinical appl...

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Bibliographic Details
Main Authors: Federica De Gaetano, Angela Scala, Consuelo Celesti, Kim Lambertsen Larsen, Fabio Genovese, Corrado Bongiorno, Loredana Leggio, Nunzio Iraci, Antonino Mazzaglia, Cinzia Anna Ventura
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
amphiphilic cyclodextrins
nanoparticles
idebenone
NMR studies
molecular modeling
in vitro antioxidant activity
Online Access:https://www.mdpi.com/1420-3049/28/7/3023

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