Macrocybin, a Natural Mushroom Triglyceride, Reduces Tumor Growth In Vitro and In Vivo through Caveolin-Mediated Interference with the Actin Cytoskeleton

Macrocybin, a Natural Mushroom Triglyceride, Reduces Tumor Growth In Vitro and In Vivo through Caveolin-Mediated Interference with the Actin Cytoskeleton

Mushrooms have been used for millennia as cancer remedies. Our goal was to screen several mushroom species from the rainforests of Costa Rica, looking for new antitumor molecules. Mushroom extracts were screened using two human cell lines: A549 (lung adenocarcinoma) and NL20 (immortalized normal lun...

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Bibliographic Details
Main Authors: Marcos Vilariño, Josune García-Sanmartín, Laura Ochoa-Callejero, Alberto López-Rodríguez, Jaime Blanco-Urgoiti, Alfredo Martínez
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
natural product
therapeutic triglyceride
xenograft study
Caveolin-1
actin cytoskeleton
Online Access:https://www.mdpi.com/1420-3049/25/24/6010

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