The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes
Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural cells, myocytes, cardiomyocytes, adipocytes, endothelial cells, melanocytes, and hepatocytes. Odontoblastic differentiation o...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1174579/full |
| _version_ | 1797674017032765440 |
|---|---|
| author | Houwen Pan Houwen Pan Houwen Pan Houwen Pan Houwen Pan Houwen Pan Yiling Yang Yiling Yang Yiling Yang Yiling Yang Yiling Yang Yiling Yang Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Anting Jin Anting Jin Anting Jin Anting Jin Anting Jin Anting Jin Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xin Gao Xin Gao Xin Gao Xin Gao Xin Gao Xin Gao Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang |
| author_facet | Houwen Pan Houwen Pan Houwen Pan Houwen Pan Houwen Pan Houwen Pan Yiling Yang Yiling Yang Yiling Yang Yiling Yang Yiling Yang Yiling Yang Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Anting Jin Anting Jin Anting Jin Anting Jin Anting Jin Anting Jin Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xin Gao Xin Gao Xin Gao Xin Gao Xin Gao Xin Gao Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang |
| author_sort | Houwen Pan |
| collection | DOAJ |
| description | Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural cells, myocytes, cardiomyocytes, adipocytes, endothelial cells, melanocytes, and hepatocytes. Odontoblastic differentiation of DMSCs is pivotal in dentinogenesis, a delicate and dynamic process regulated at the molecular level by signaling pathways, transcription factors, and posttranscriptional and epigenetic regulation. Mutations or dysregulation of related genes may contribute to genetic diseases with dentin defects caused by impaired odontoblastic differentiation, including tricho-dento-osseous (TDO) syndrome, X-linked hypophosphatemic rickets (XLH), Raine syndrome (RS), hypophosphatasia (HPP), Schimke immuno-osseous dysplasia (SIOD), and Elsahy-Waters syndrome (EWS). Herein, recent progress in the molecular regulation of the odontoblastic differentiation of DMSCs is summarized. In addition, genetic syndromes associated with disorders of odontoblastic differentiation of DMSCs are discussed. An improved understanding of the molecular regulation and related genetic syndromes may help clinicians better understand the etiology and pathogenesis of dentin lesions in systematic diseases and identify novel treatment targets. |
| first_indexed | 2024-03-11T21:54:07Z |
| format | Article |
| id | doaj.art-ce6498d3954c4327b406eb73171f1cfc |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T21:54:07Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ce6498d3954c4327b406eb73171f1cfc2023-09-26T05:52:12ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-09-011110.3389/fcell.2023.11745791174579The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromesHouwen Pan0Houwen Pan1Houwen Pan2Houwen Pan3Houwen Pan4Houwen Pan5Yiling Yang6Yiling Yang7Yiling Yang8Yiling Yang9Yiling Yang10Yiling Yang11Hongyuan Xu12Hongyuan Xu13Hongyuan Xu14Hongyuan Xu15Hongyuan Xu16Hongyuan Xu17Anting Jin18Anting Jin19Anting Jin20Anting Jin21Anting Jin22Anting Jin23Xiangru Huang24Xiangru Huang25Xiangru Huang26Xiangru Huang27Xiangru Huang28Xiangru Huang29Xin Gao30Xin Gao31Xin Gao32Xin Gao33Xin Gao34Xin Gao35Siyuan Sun36Siyuan Sun37Siyuan Sun38Siyuan Sun39Siyuan Sun40Siyuan Sun41Yuanqi Liu42Yuanqi Liu43Yuanqi Liu44Yuanqi Liu45Yuanqi Liu46Yuanqi Liu47Jingyi Liu48Jingyi Liu49Jingyi Liu50Jingyi Liu51Jingyi Liu52Jingyi Liu53Tingwei Lu54Tingwei Lu55Tingwei Lu56Tingwei Lu57Tingwei Lu58Tingwei Lu59Xinyu Wang60Xinyu Wang61Xinyu Wang62Xinyu Wang63Xinyu Wang64Xinyu Wang65Yanfei Zhu66Yanfei Zhu67Yanfei Zhu68Yanfei Zhu69Yanfei Zhu70Yanfei Zhu71Lingyong Jiang72Lingyong Jiang73Lingyong Jiang74Lingyong Jiang75Lingyong Jiang76Lingyong Jiang77Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaCenter of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, Shanghai, ChinaNational Clinical Research Center for Oral Disease, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Shanghai, ChinaShanghai Research Institute of Stomatology, Shanghai, ChinaDental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural cells, myocytes, cardiomyocytes, adipocytes, endothelial cells, melanocytes, and hepatocytes. Odontoblastic differentiation of DMSCs is pivotal in dentinogenesis, a delicate and dynamic process regulated at the molecular level by signaling pathways, transcription factors, and posttranscriptional and epigenetic regulation. Mutations or dysregulation of related genes may contribute to genetic diseases with dentin defects caused by impaired odontoblastic differentiation, including tricho-dento-osseous (TDO) syndrome, X-linked hypophosphatemic rickets (XLH), Raine syndrome (RS), hypophosphatasia (HPP), Schimke immuno-osseous dysplasia (SIOD), and Elsahy-Waters syndrome (EWS). Herein, recent progress in the molecular regulation of the odontoblastic differentiation of DMSCs is summarized. In addition, genetic syndromes associated with disorders of odontoblastic differentiation of DMSCs are discussed. An improved understanding of the molecular regulation and related genetic syndromes may help clinicians better understand the etiology and pathogenesis of dentin lesions in systematic diseases and identify novel treatment targets.https://www.frontiersin.org/articles/10.3389/fcell.2023.1174579/fullodontoblastic differentiationdental mesenchymal stem cellsmolecular regulationsignaling pathwaygenetic syndrome |
| spellingShingle | Houwen Pan Houwen Pan Houwen Pan Houwen Pan Houwen Pan Houwen Pan Yiling Yang Yiling Yang Yiling Yang Yiling Yang Yiling Yang Yiling Yang Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Hongyuan Xu Anting Jin Anting Jin Anting Jin Anting Jin Anting Jin Anting Jin Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xiangru Huang Xin Gao Xin Gao Xin Gao Xin Gao Xin Gao Xin Gao Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Siyuan Sun Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Yuanqi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Jingyi Liu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Tingwei Lu Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Xinyu Wang Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Yanfei Zhu Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang Lingyong Jiang The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes Frontiers in Cell and Developmental Biology odontoblastic differentiation dental mesenchymal stem cells molecular regulation signaling pathway genetic syndrome |
| title | The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes |
| title_full | The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes |
| title_fullStr | The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes |
| title_full_unstemmed | The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes |
| title_short | The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes |
| title_sort | odontoblastic differentiation of dental mesenchymal stem cells molecular regulation mechanism and related genetic syndromes |
| topic | odontoblastic differentiation dental mesenchymal stem cells molecular regulation signaling pathway genetic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1174579/full |
| work_keys_str_mv | AT houwenpan theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang theodontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT houwenpan odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yilingyang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT hongyuanxu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT antingjin odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xiangruhuang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xingao odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT siyuansun odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yuanqiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT jingyiliu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT tingweilu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT xinyuwang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT yanfeizhu odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes AT lingyongjiang odontoblasticdifferentiationofdentalmesenchymalstemcellsmolecularregulationmechanismandrelatedgeneticsyndromes |