Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies
Abstract The authors investigated the association between obstructive sleep apnea (OSA) and right ventricular (RV) systolic dysfunction trough a meta‐analysis of echocardiographic studies providing data on RV mechanics as assessed by longitudinal strain (LS). A systematic search was conducted using...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14550 |
| _version_ | 1827778911768936448 |
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| author | Marijana Tadic Elisa Gherbesi Andrea Faggiano Carla Sala Stefano Carugo Cesare Cuspidi |
| author_facet | Marijana Tadic Elisa Gherbesi Andrea Faggiano Carla Sala Stefano Carugo Cesare Cuspidi |
| author_sort | Marijana Tadic |
| collection | DOAJ |
| description | Abstract The authors investigated the association between obstructive sleep apnea (OSA) and right ventricular (RV) systolic dysfunction trough a meta‐analysis of echocardiographic studies providing data on RV mechanics as assessed by longitudinal strain (LS). A systematic search was conducted using PubMed, OVID‐MEDLINE, and Cochrane library databases to search English‐language review papers published from inception to March 31, 2022. Only studies reporting data on RV free‐wall or global LS in patients with OSA of different severity and non‐OSA controls were reviewed. Data of interest were pooled to obtain standard means difference (SMD) with 95% confidence interval (CI). The meta‐analysis included 628 participants (436 with OSA and 192 controls) from eight studies. Compared to controls, RV free wall LS was significantly reduced in the pooled OSA group (SMD 1.02 ± .33, CI:.17/1.24, P < .002); this was also the case for RV global LS (SMD: .72 ± .11, CI: .50/.93, P < .0001). Notably, compared to patients with mild‐OSA those with moderate and severe OSA exhibited significantly lower RV free‐wall LS and global LS values; this was not the case for tricuspid annular plane excursion. In conclusions, both RV free‐wall and global LS are impaired in patients with OSA; deterioration of these indices, unlike TAPSE, was already evident in the early stages and was related to the severity of the syndrome. Thus, RV myocardial strain should be considered to be included in echocardiographic evaluation of OSA patients in order to detect subclinical cardiac damage in these patients regardless of its degree of severity. |
| first_indexed | 2024-03-11T14:43:47Z |
| format | Article |
| id | doaj.art-ce64a12858f34be995916b4475366ebd |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:47Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-ce64a12858f34be995916b4475366ebd2023-10-30T13:26:22ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-10-0124101247125410.1111/jch.14550Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studiesMarijana Tadic0Elisa Gherbesi1Andrea Faggiano2Carla Sala3Stefano Carugo4Cesare Cuspidi5University Clinical Hospital Centre “Dragisa Misovic” Belgrade SerbiaDepartment of Clinical Sciences and Community Health University of Milano and Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano Milano ItalyDepartment of Clinical Sciences and Community Health University of Milano and Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano Milano ItalyDepartment of Clinical Sciences and Community Health University of Milano and Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano Milano ItalyDepartment of Clinical Sciences and Community Health University of Milano and Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano Milano ItalyDepartment of Medicine and Surgery University of Milano‐Bicocca Milano ItalyAbstract The authors investigated the association between obstructive sleep apnea (OSA) and right ventricular (RV) systolic dysfunction trough a meta‐analysis of echocardiographic studies providing data on RV mechanics as assessed by longitudinal strain (LS). A systematic search was conducted using PubMed, OVID‐MEDLINE, and Cochrane library databases to search English‐language review papers published from inception to March 31, 2022. Only studies reporting data on RV free‐wall or global LS in patients with OSA of different severity and non‐OSA controls were reviewed. Data of interest were pooled to obtain standard means difference (SMD) with 95% confidence interval (CI). The meta‐analysis included 628 participants (436 with OSA and 192 controls) from eight studies. Compared to controls, RV free wall LS was significantly reduced in the pooled OSA group (SMD 1.02 ± .33, CI:.17/1.24, P < .002); this was also the case for RV global LS (SMD: .72 ± .11, CI: .50/.93, P < .0001). Notably, compared to patients with mild‐OSA those with moderate and severe OSA exhibited significantly lower RV free‐wall LS and global LS values; this was not the case for tricuspid annular plane excursion. In conclusions, both RV free‐wall and global LS are impaired in patients with OSA; deterioration of these indices, unlike TAPSE, was already evident in the early stages and was related to the severity of the syndrome. Thus, RV myocardial strain should be considered to be included in echocardiographic evaluation of OSA patients in order to detect subclinical cardiac damage in these patients regardless of its degree of severity.https://doi.org/10.1111/jch.14550meta‐analysisobstructive sleep apnearight ventricular straintricuspid annular plane excursion |
| spellingShingle | Marijana Tadic Elisa Gherbesi Andrea Faggiano Carla Sala Stefano Carugo Cesare Cuspidi Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies The Journal of Clinical Hypertension meta‐analysis obstructive sleep apnea right ventricular strain tricuspid annular plane excursion |
| title | Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies |
| title_full | Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies |
| title_fullStr | Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies |
| title_full_unstemmed | Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies |
| title_short | Obstructive sleep apnea and right ventricular function: A meta‐analysis of speckle tracking echocardiographic studies |
| title_sort | obstructive sleep apnea and right ventricular function a meta analysis of speckle tracking echocardiographic studies |
| topic | meta‐analysis obstructive sleep apnea right ventricular strain tricuspid annular plane excursion |
| url | https://doi.org/10.1111/jch.14550 |
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