Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice
Abstract Objective To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse w...
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Format: | Article |
Language: | English |
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BMC
2018-07-01
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Series: | Biological Research |
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Online Access: | http://link.springer.com/article/10.1186/s40659-018-0166-7 |
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author | Ruhui Lin Long Li Yingzheng Zhang Sheng Huang Shangjie Chen Jiao Shi Peiyuan Zhuo Hao Jin Zuanfang Li Weilin Liu Zhifu Wang Lidian Chen Jing Tao |
author_facet | Ruhui Lin Long Li Yingzheng Zhang Sheng Huang Shangjie Chen Jiao Shi Peiyuan Zhuo Hao Jin Zuanfang Li Weilin Liu Zhifu Wang Lidian Chen Jing Tao |
author_sort | Ruhui Lin |
collection | DOAJ |
description | Abstract Objective To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. Results EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. Conclusion These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice. |
first_indexed | 2024-04-13T03:26:42Z |
format | Article |
id | doaj.art-ce66319847d64184998258cb7ff436fa |
institution | Directory Open Access Journal |
issn | 0717-6287 |
language | English |
last_indexed | 2024-04-13T03:26:42Z |
publishDate | 2018-07-01 |
publisher | BMC |
record_format | Article |
series | Biological Research |
spelling | doaj.art-ce66319847d64184998258cb7ff436fa2022-12-22T03:04:38ZengBMCBiological Research0717-62872018-07-0151111010.1186/s40659-018-0166-7Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 miceRuhui Lin0Long Li1Yingzheng Zhang2Sheng Huang3Shangjie Chen4Jiao Shi5Peiyuan Zhuo6Hao Jin7Zuanfang Li8Weilin Liu9Zhifu Wang10Lidian Chen11Jing Tao12Fujian Collaborative Innovation Center for Rehabilitation TechnologyFujian Collaborative Innovation Center for Rehabilitation TechnologyFujian Collaborative Innovation Center for Rehabilitation TechnologyTCM Rehabilitation Research Center of SATCMBaoan People’s Hospital Affiliated to Southern Medical UniversityBaoan People’s Hospital Affiliated to Southern Medical UniversityFujian Collaborative Innovation Center for Rehabilitation TechnologyTCM Rehabilitation Research Center of SATCMNational-Local Joint Engineering Research Center of Rehabilitation Medicine TechnologyCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese MedicineNational-Local Joint Engineering Research Center of Rehabilitation Medicine TechnologyNational-Local Joint Engineering Research Center of Rehabilitation Medicine TechnologyCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese MedicineAbstract Objective To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. Results EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. Conclusion These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.http://link.springer.com/article/10.1186/s40659-018-0166-7Magnetic resonance spectroscopy (MRS)ElectroacupunctureLearning and memoryN-Acetylaspartate (NAA)Glutamate (Glu) |
spellingShingle | Ruhui Lin Long Li Yingzheng Zhang Sheng Huang Shangjie Chen Jiao Shi Peiyuan Zhuo Hao Jin Zuanfang Li Weilin Liu Zhifu Wang Lidian Chen Jing Tao Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice Biological Research Magnetic resonance spectroscopy (MRS) Electroacupuncture Learning and memory N-Acetylaspartate (NAA) Glutamate (Glu) |
title | Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice |
title_full | Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice |
title_fullStr | Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice |
title_full_unstemmed | Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice |
title_short | Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice |
title_sort | electroacupuncture ameliorate learning and memory by improving n acetylaspartate and glutamate metabolism in app ps1 mice |
topic | Magnetic resonance spectroscopy (MRS) Electroacupuncture Learning and memory N-Acetylaspartate (NAA) Glutamate (Glu) |
url | http://link.springer.com/article/10.1186/s40659-018-0166-7 |
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