Modern approaches to drug therapy of bladder cancer after first progression.
The number of drugs that is effective in urothelial cancer is very little. Cisplatin remains the basic drug for first line, but its use may be limited because of significant toxic reactions, that develop in a great number of patients. In case of impossibility of use of platinum derivatives treatment...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
QUASAR, LLC
2015-06-01
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| Series: | Issledovaniâ i Praktika v Medicine |
| Subjects: | |
| Online Access: | https://www.rpmj.ru/rpmj/article/view/60 |
| _version_ | 1797874161161338880 |
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| author | L. V. Bolotina L. A. Koroleva |
| author_facet | L. V. Bolotina L. A. Koroleva |
| author_sort | L. V. Bolotina |
| collection | DOAJ |
| description | The number of drugs that is effective in urothelial cancer is very little. Cisplatin remains the basic drug for first line, but its use may be limited because of significant toxic reactions, that develop in a great number of patients. In case of impossibility of use of platinum derivatives treatment may be limited to the use of gemcitabine as monotherapy. It is much more difficult to resolve the issue regarding patients progressing after 1st line treatment. The effectiveness of ifosfamide, taxanes, topotecan, epitilon B, pemetrexed, nab-paclitaxel, pralatrexate, targeted drugs or their combinations had not lived up to expectations. Vinflunine (Javlor) is the innovative chemotherapeutic drug that is effective for the treatment of platinum-refractory urotelial cancer, including a phase-3 trial. We have our own positive experience with Javlor in older age group of patients, that is presented in the article |
| first_indexed | 2024-04-10T01:27:38Z |
| format | Article |
| id | doaj.art-ce673203de0940628c086c2876ae3ca2 |
| institution | Directory Open Access Journal |
| issn | 2410-1893 |
| language | Russian |
| last_indexed | 2024-04-10T01:27:38Z |
| publishDate | 2015-06-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Issledovaniâ i Praktika v Medicine |
| spelling | doaj.art-ce673203de0940628c086c2876ae3ca22023-03-13T09:34:58ZrusQUASAR, LLCIssledovaniâ i Praktika v Medicine2410-18932015-06-0122293410.17709/2409-2231-2015-2-2-29-3439Modern approaches to drug therapy of bladder cancer after first progression.L. V. Bolotina0L. A. Koroleva1МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИРЦ» Минздрава России 125284, Российская Федерация, г. Москва, 2-ой Боткинский проезд, дом 3МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИРЦ» Минздрава России 125284, Российская Федерация, г. Москва, 2-ой Боткинский проезд, дом 3The number of drugs that is effective in urothelial cancer is very little. Cisplatin remains the basic drug for first line, but its use may be limited because of significant toxic reactions, that develop in a great number of patients. In case of impossibility of use of platinum derivatives treatment may be limited to the use of gemcitabine as monotherapy. It is much more difficult to resolve the issue regarding patients progressing after 1st line treatment. The effectiveness of ifosfamide, taxanes, topotecan, epitilon B, pemetrexed, nab-paclitaxel, pralatrexate, targeted drugs or their combinations had not lived up to expectations. Vinflunine (Javlor) is the innovative chemotherapeutic drug that is effective for the treatment of platinum-refractory urotelial cancer, including a phase-3 trial. We have our own positive experience with Javlor in older age group of patients, that is presented in the articlehttps://www.rpmj.ru/rpmj/article/view/60платинорефрактерный уротелиальный рак, винфлунин |
| spellingShingle | L. V. Bolotina L. A. Koroleva Modern approaches to drug therapy of bladder cancer after first progression. Issledovaniâ i Praktika v Medicine платинорефрактерный уротелиальный рак, винфлунин |
| title | Modern approaches to drug therapy of bladder cancer after first progression. |
| title_full | Modern approaches to drug therapy of bladder cancer after first progression. |
| title_fullStr | Modern approaches to drug therapy of bladder cancer after first progression. |
| title_full_unstemmed | Modern approaches to drug therapy of bladder cancer after first progression. |
| title_short | Modern approaches to drug therapy of bladder cancer after first progression. |
| title_sort | modern approaches to drug therapy of bladder cancer after first progression |
| topic | платинорефрактерный уротелиальный рак, винфлунин |
| url | https://www.rpmj.ru/rpmj/article/view/60 |
| work_keys_str_mv | AT lvbolotina modernapproachestodrugtherapyofbladdercancerafterfirstprogression AT lakoroleva modernapproachestodrugtherapyofbladdercancerafterfirstprogression |