A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Abstract Background and aims As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non‐hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes. Methods W...

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Bibliographic Details
Main Authors: Mohammad Rafiee, Mohammad Abbasi, Hassan Rafieemehr, Amin Mirzaeian, Mohieddin Barzegar, Vahid Amiri, Shaghayegh Shahsavan, Mohammad Hossein Mohammadi
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Health Science Reports
Subjects:
Online Access:https://doi.org/10.1002/hsr2.282
Description
Summary:Abstract Background and aims As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non‐hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes. Methods We had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included. Results Here we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdisease, and Mobilization. Also, the prediction of hematological reconstitutionand some novel suggestions leading to better outcomes are reviewed. Conclusion The study will be applicable for improvedmanagement of autologous and allogeneic HSCT process to increase the procedureefficiency.
ISSN:2398-8835