Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence

Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence

Abstract Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical stress-induced nuclear/DNA damage, however, its molecular mechanisms remain much unknown. Our recent study of Hutchinson-Gilford progeria syndrome (HGPS) disease revealed the role of nuclear membrane prot...

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Bibliographic Details
Main Authors: Xianlin Yue, Jie Cui, Zewei Sun, Lei Liu, Ying Li, Liwei Shao, Qi Feng, Ziyue Wang, William S. Hambright, Yan Cui, Johnny Huard, Yanling Mu, Xiaodong Mu
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01467-1

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