Evaluation of Membrane Permeability of Copper-Based Drugs
Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl<sub>2</sub> as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
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| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/11/5/179 |
| Summary: | Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl<sub>2</sub> as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2 to 7. Octanol/water partition coefficients (log <i>K<sub>o/w</sub></i>) were measured and correlated with the permeability coefficients (<i>K<sub>p</sub></i>). In addition, chemical speciation was used to determine the predominant complex in solution at physiological pH. No correlation was found between the measured permeability coefficients and either molecular weight (MW) or log <i>K<sub>o/w</sub></i>. |
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| ISSN: | 2304-6740 |