Evaluation of Membrane Permeability of Copper-Based Drugs
Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl<sub>2</sub> as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/11/5/179 |
| _version_ | 1797599766594453504 |
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| author | Evariste Umba-Tsumbu Ahmed N. Hammouda Graham Ellis Jackson |
| author_facet | Evariste Umba-Tsumbu Ahmed N. Hammouda Graham Ellis Jackson |
| author_sort | Evariste Umba-Tsumbu |
| collection | DOAJ |
| description | Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl<sub>2</sub> as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2 to 7. Octanol/water partition coefficients (log <i>K<sub>o/w</sub></i>) were measured and correlated with the permeability coefficients (<i>K<sub>p</sub></i>). In addition, chemical speciation was used to determine the predominant complex in solution at physiological pH. No correlation was found between the measured permeability coefficients and either molecular weight (MW) or log <i>K<sub>o/w</sub></i>. |
| first_indexed | 2024-03-11T03:38:58Z |
| format | Article |
| id | doaj.art-ce6d94b35b034298b302d3fc1911da9d |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-11T03:38:58Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-ce6d94b35b034298b302d3fc1911da9d2023-11-18T01:48:39ZengMDPI AGInorganics2304-67402023-04-0111517910.3390/inorganics11050179Evaluation of Membrane Permeability of Copper-Based DrugsEvariste Umba-Tsumbu0Ahmed N. Hammouda1Graham Ellis Jackson2Department of Chemistry, University of Cape Town, Cape Town 7701, South AfricaDepartment of Chemistry, University of Cape Town, Cape Town 7701, South AfricaDepartment of Chemistry, University of Cape Town, Cape Town 7701, South AfricaMembrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl<sub>2</sub> as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2 to 7. Octanol/water partition coefficients (log <i>K<sub>o/w</sub></i>) were measured and correlated with the permeability coefficients (<i>K<sub>p</sub></i>). In addition, chemical speciation was used to determine the predominant complex in solution at physiological pH. No correlation was found between the measured permeability coefficients and either molecular weight (MW) or log <i>K<sub>o/w</sub></i>.https://www.mdpi.com/2304-6740/11/5/179transdermal drug deliveryabsorption enhancertissue partitiondiffusionpermeabilityCerasome 9005 |
| spellingShingle | Evariste Umba-Tsumbu Ahmed N. Hammouda Graham Ellis Jackson Evaluation of Membrane Permeability of Copper-Based Drugs Inorganics transdermal drug delivery absorption enhancer tissue partition diffusion permeability Cerasome 9005 |
| title | Evaluation of Membrane Permeability of Copper-Based Drugs |
| title_full | Evaluation of Membrane Permeability of Copper-Based Drugs |
| title_fullStr | Evaluation of Membrane Permeability of Copper-Based Drugs |
| title_full_unstemmed | Evaluation of Membrane Permeability of Copper-Based Drugs |
| title_short | Evaluation of Membrane Permeability of Copper-Based Drugs |
| title_sort | evaluation of membrane permeability of copper based drugs |
| topic | transdermal drug delivery absorption enhancer tissue partition diffusion permeability Cerasome 9005 |
| url | https://www.mdpi.com/2304-6740/11/5/179 |
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