Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site
Dural metastases are uncommon in cancer patients, but can have as much of an effect on the lives of patients as brain metastases. Dural metastases are most commonly associated with primary cancers of the breast, prostate, and lung, and it is rare that the primary site of the tumor is unknown. In thi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2019-08-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/502416 |
| _version_ | 1818217910852648960 |
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| author | Hiroyuki Takeda Rintaro Ohe Tadahisa Fukui Shuhei Suzuki Sho Nakamura Kaname Watanabe Takashi Yoshioka |
| author_facet | Hiroyuki Takeda Rintaro Ohe Tadahisa Fukui Shuhei Suzuki Sho Nakamura Kaname Watanabe Takashi Yoshioka |
| author_sort | Hiroyuki Takeda |
| collection | DOAJ |
| description | Dural metastases are uncommon in cancer patients, but can have as much of an effect on the lives of patients as brain metastases. Dural metastases are most commonly associated with primary cancers of the breast, prostate, and lung, and it is rare that the primary site of the tumor is unknown. In this study, we encountered a 51-year-old woman who had developed multiple bone tumors, with no known primary cancer lesion. A tumor biopsy of the sacral bone revealed non-keratinizing squamous cell carcinoma; the patient was therefore diagnosed as having multiple bone metastases of an unknown primary cancer. Magnetic resonance imaging revealed cranial metastases and partial thickening of the dura with suspected dura metastases. Platinum-based chemotherapy reduced the bone metastases and the thickened dura. However, as resistance to chemotherapy developed, invasions progressed rapidly and diffusely throughout the dura. This was accompanied by the development of dysarthria, visual impairments, and delirium. The patient died 10 months after being diagnosed with dural metastases. This report provides information on the clinical course and prognosis of patients with dural metastases of unknown primary cancer. Furthermore, it may help to construct a treatment strategy for dural metastases. |
| first_indexed | 2024-12-12T07:15:23Z |
| format | Article |
| id | doaj.art-ce6eb514e9da4985988d4338ce3b6ae8 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-12T07:15:23Z |
| publishDate | 2019-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-ce6eb514e9da4985988d4338ce3b6ae82022-12-22T00:33:32ZengKarger PublishersCase Reports in Oncology1662-65752019-08-0112266667010.1159/000502416502416Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary SiteHiroyuki TakedaRintaro OheTadahisa FukuiShuhei SuzukiSho NakamuraKaname WatanabeTakashi YoshiokaDural metastases are uncommon in cancer patients, but can have as much of an effect on the lives of patients as brain metastases. Dural metastases are most commonly associated with primary cancers of the breast, prostate, and lung, and it is rare that the primary site of the tumor is unknown. In this study, we encountered a 51-year-old woman who had developed multiple bone tumors, with no known primary cancer lesion. A tumor biopsy of the sacral bone revealed non-keratinizing squamous cell carcinoma; the patient was therefore diagnosed as having multiple bone metastases of an unknown primary cancer. Magnetic resonance imaging revealed cranial metastases and partial thickening of the dura with suspected dura metastases. Platinum-based chemotherapy reduced the bone metastases and the thickened dura. However, as resistance to chemotherapy developed, invasions progressed rapidly and diffusely throughout the dura. This was accompanied by the development of dysarthria, visual impairments, and delirium. The patient died 10 months after being diagnosed with dural metastases. This report provides information on the clinical course and prognosis of patients with dural metastases of unknown primary cancer. Furthermore, it may help to construct a treatment strategy for dural metastases.https://www.karger.com/Article/FullText/502416Dural metastasesCarcinoma of unknown primary sitePrognosisChemotherapy |
| spellingShingle | Hiroyuki Takeda Rintaro Ohe Tadahisa Fukui Shuhei Suzuki Sho Nakamura Kaname Watanabe Takashi Yoshioka Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site Case Reports in Oncology Dural metastases Carcinoma of unknown primary site Prognosis Chemotherapy |
| title | Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site |
| title_full | Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site |
| title_fullStr | Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site |
| title_full_unstemmed | Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site |
| title_short | Rapid Progression of Intracranial Dural Metastases in a Patient with Carcinoma of Unknown Primary Site |
| title_sort | rapid progression of intracranial dural metastases in a patient with carcinoma of unknown primary site |
| topic | Dural metastases Carcinoma of unknown primary site Prognosis Chemotherapy |
| url | https://www.karger.com/Article/FullText/502416 |
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