Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men
Background/objectives: Exercise intensity is potentially an important regulator of various exerkines secretion, but the optimal exercise intensity to increase and sustain exerkines levels, including FGF-21, FSTL-1, cathepsin B, and BDNF in humans, has not yet been fully elucidated. This study aimed...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Exercise Science & Fitness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1728869X2300062X |
| _version_ | 1797346050488401920 |
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| author | Minje Ji Chaeeun Cho Sewon Lee |
| author_facet | Minje Ji Chaeeun Cho Sewon Lee |
| author_sort | Minje Ji |
| collection | DOAJ |
| description | Background/objectives: Exercise intensity is potentially an important regulator of various exerkines secretion, but the optimal exercise intensity to increase and sustain exerkines levels, including FGF-21, FSTL-1, cathepsin B, and BDNF in humans, has not yet been fully elucidated. This study aimed to examine the circulating levels of FGF-21, FSTL-1, cathepsin B, and BDNF according to the exercise intensity. Methods: Nine young men (24.0 ± 0.4 years old) performed 4 different experimental sessions at 1-week intervals: 1) a control session (CTRL; no exercise); 2) moderate-intensity continuous exercise (MICE, 55% HRR); 3) vigorous-intensity continuous exercise (VICE, 85% HRR); and 4) high-intensity interval exercise (HIIE, 4 repetitions of a 30-s of “all out” cycling workout followed by a 4-min recovery). Blood samples were collected at 4 different time points (pre-exercise, immediately post-exercise, 30 min post-exercise, and 90 min post-exercise). Results: Serum FGF-21, FSTL-1, cathepsin B, and BDNF were higher in HIIE than in CTRL immediately post-exercise, and FSTL-1, cathepsin B, and BDNF were higher in HIIE than in MICE immediately post-exercise (P < 0.05). The AUC for FGF-21, FSTL-1, and BDNF was higher in HIIE than in CTRL, and the AUC for FGF-21 and BDNF was higher in HIIE than in MICE (P < 0.05). Furthermore, the change in blood lactate was positively correlated with the changes in all exerkines. Conclusions: This study demonstrates that acute HIIE effectively increases serum FGF-21, FSTL-1, cathepsin B, and BDNF compared to MICE. Therefore, the secretion of exerkines, including FGF-21, FSTL-1, cathepsin B, and BDNF may be exercise intensity-dependent. |
| first_indexed | 2024-03-08T11:27:17Z |
| format | Article |
| id | doaj.art-ce71d11756ea4aa2934699f673a4818d |
| institution | Directory Open Access Journal |
| issn | 1728-869X |
| language | English |
| last_indexed | 2024-03-08T11:27:17Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Exercise Science & Fitness |
| spelling | doaj.art-ce71d11756ea4aa2934699f673a4818d2024-01-26T05:32:33ZengElsevierJournal of Exercise Science & Fitness1728-869X2024-01-012215158Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young menMinje Ji0Chaeeun Cho1Sewon Lee2Department of Human Movement Science, Graduate School, Incheon National University, Incheon, Republic of KoreaDepartment of Human Movement Science, Graduate School, Incheon National University, Incheon, Republic of KoreaDivision of Sport Science, College of Arts & Physical Education, Incheon National University, Incheon, Republic of Korea; Sport Science Institute, College of Arts & Physical Education, Incheon National University, Incheon, Republic of Korea; Health Promotion Center, College of Arts & Physical Education, Incheon National University, Incheon, Republic of Korea; Corresponding author. Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Bldg# 16, Room# 423, (Songdo-dong) 119 Academy-ro, Yeonsu-gu, Incheon, Republic of Korea.Background/objectives: Exercise intensity is potentially an important regulator of various exerkines secretion, but the optimal exercise intensity to increase and sustain exerkines levels, including FGF-21, FSTL-1, cathepsin B, and BDNF in humans, has not yet been fully elucidated. This study aimed to examine the circulating levels of FGF-21, FSTL-1, cathepsin B, and BDNF according to the exercise intensity. Methods: Nine young men (24.0 ± 0.4 years old) performed 4 different experimental sessions at 1-week intervals: 1) a control session (CTRL; no exercise); 2) moderate-intensity continuous exercise (MICE, 55% HRR); 3) vigorous-intensity continuous exercise (VICE, 85% HRR); and 4) high-intensity interval exercise (HIIE, 4 repetitions of a 30-s of “all out” cycling workout followed by a 4-min recovery). Blood samples were collected at 4 different time points (pre-exercise, immediately post-exercise, 30 min post-exercise, and 90 min post-exercise). Results: Serum FGF-21, FSTL-1, cathepsin B, and BDNF were higher in HIIE than in CTRL immediately post-exercise, and FSTL-1, cathepsin B, and BDNF were higher in HIIE than in MICE immediately post-exercise (P < 0.05). The AUC for FGF-21, FSTL-1, and BDNF was higher in HIIE than in CTRL, and the AUC for FGF-21 and BDNF was higher in HIIE than in MICE (P < 0.05). Furthermore, the change in blood lactate was positively correlated with the changes in all exerkines. Conclusions: This study demonstrates that acute HIIE effectively increases serum FGF-21, FSTL-1, cathepsin B, and BDNF compared to MICE. Therefore, the secretion of exerkines, including FGF-21, FSTL-1, cathepsin B, and BDNF may be exercise intensity-dependent.http://www.sciencedirect.com/science/article/pii/S1728869X2300062XExerkineLactateHIIEWingate testMyokine |
| spellingShingle | Minje Ji Chaeeun Cho Sewon Lee Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men Journal of Exercise Science & Fitness Exerkine Lactate HIIE Wingate test Myokine |
| title | Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men |
| title_full | Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men |
| title_fullStr | Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men |
| title_full_unstemmed | Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men |
| title_short | Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men |
| title_sort | acute effect of exercise intensity on circulating fgf 21 fstl 1 cathepsin b and bdnf in young men |
| topic | Exerkine Lactate HIIE Wingate test Myokine |
| url | http://www.sciencedirect.com/science/article/pii/S1728869X2300062X |
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