Causal relationship between insulin resistance and sarcopenia
Abstract Sarcopenia is a multifactorial disease characterized by reduced muscle mass and function, leading to disability, death, and other diseases. Recently, the prevalence of sarcopenia increased considerably, posing a serious threat to health worldwide. However, no clear international consensus h...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01022-z |
| _version_ | 1797864043578392576 |
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| author | Zi-jian Liu Cui-feng Zhu |
| author_facet | Zi-jian Liu Cui-feng Zhu |
| author_sort | Zi-jian Liu |
| collection | DOAJ |
| description | Abstract Sarcopenia is a multifactorial disease characterized by reduced muscle mass and function, leading to disability, death, and other diseases. Recently, the prevalence of sarcopenia increased considerably, posing a serious threat to health worldwide. However, no clear international consensus has been reached regarding the etiology of sarcopenia. Several studies have shown that insulin resistance may be an important mechanism in the pathogenesis of induced muscle attenuation and that, conversely, sarcopenia can lead to insulin resistance. However, the causal relationship between the two is not clear. In this paper, the pathogenesis of sarcopenia is analyzed, the possible intrinsic causal relationship between sarcopenia and insulin resistance examined, and research progress expounded to provide a basis for the clinical diagnosis, treatment, and study of the mechanism of sarcopenia. |
| first_indexed | 2024-04-09T22:45:16Z |
| format | Article |
| id | doaj.art-ce71dc27487a4d6fab8a1e5266776d0d |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-09T22:45:16Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-ce71dc27487a4d6fab8a1e5266776d0d2023-03-22T11:55:49ZengBMCDiabetology & Metabolic Syndrome1758-59962023-03-0115111510.1186/s13098-023-01022-zCausal relationship between insulin resistance and sarcopeniaZi-jian Liu0Cui-feng Zhu1Shenzhen Clinical Medical College, Southern Medical UniversityShenzhen Hospital of Southern Medical UniversityAbstract Sarcopenia is a multifactorial disease characterized by reduced muscle mass and function, leading to disability, death, and other diseases. Recently, the prevalence of sarcopenia increased considerably, posing a serious threat to health worldwide. However, no clear international consensus has been reached regarding the etiology of sarcopenia. Several studies have shown that insulin resistance may be an important mechanism in the pathogenesis of induced muscle attenuation and that, conversely, sarcopenia can lead to insulin resistance. However, the causal relationship between the two is not clear. In this paper, the pathogenesis of sarcopenia is analyzed, the possible intrinsic causal relationship between sarcopenia and insulin resistance examined, and research progress expounded to provide a basis for the clinical diagnosis, treatment, and study of the mechanism of sarcopenia.https://doi.org/10.1186/s13098-023-01022-zInsulin resistanceSkeletal muscleProteinMitochondriaLipid infiltrationAutophagy |
| spellingShingle | Zi-jian Liu Cui-feng Zhu Causal relationship between insulin resistance and sarcopenia Diabetology & Metabolic Syndrome Insulin resistance Skeletal muscle Protein Mitochondria Lipid infiltration Autophagy |
| title | Causal relationship between insulin resistance and sarcopenia |
| title_full | Causal relationship between insulin resistance and sarcopenia |
| title_fullStr | Causal relationship between insulin resistance and sarcopenia |
| title_full_unstemmed | Causal relationship between insulin resistance and sarcopenia |
| title_short | Causal relationship between insulin resistance and sarcopenia |
| title_sort | causal relationship between insulin resistance and sarcopenia |
| topic | Insulin resistance Skeletal muscle Protein Mitochondria Lipid infiltration Autophagy |
| url | https://doi.org/10.1186/s13098-023-01022-z |
| work_keys_str_mv | AT zijianliu causalrelationshipbetweeninsulinresistanceandsarcopenia AT cuifengzhu causalrelationshipbetweeninsulinresistanceandsarcopenia |