Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children?
ABSTRACT Objective To assess cut-off value of creatinine and glomerular filtration rate for augmentation cystoplasty (AC) in paediatric age-group. Materials and Methods Data of all paediatric-patients (<18 years) with small capacity bladder, in whom AC was advised between 2005-2015 were reviewe...
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Sociedade Brasileira de Urologia
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000100156&lng=en&tlng=en |
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| author | Prempal Singh Ankur Bansal Virender Sekhon Sandeep Nunia M. S. Ansari |
| author_facet | Prempal Singh Ankur Bansal Virender Sekhon Sandeep Nunia M. S. Ansari |
| author_sort | Prempal Singh |
| collection | DOAJ |
| description | ABSTRACT Objective To assess cut-off value of creatinine and glomerular filtration rate for augmentation cystoplasty (AC) in paediatric age-group. Materials and Methods Data of all paediatric-patients (<18 years) with small capacity bladder, in whom AC was advised between 2005-2015 were reviewed. All patients were divided in two-groups, AC-group and control-group (without AC). Creatinine and e-GFR were assessed at the time of surgery, at 6 months and at last follow-up. Renal function deterioration was defined as increase in creatinine by ≥25% from baseline value or new-onset stage-3 CKD or worsening of CKD stage with pre-operative-CKD stage-3. ROCs were plotted using creatinine and e-GFR for AC. Results A total of 94 patients with mean-age 8.9 years were included. The mean creatinine and e-GFR were 1.33mg/dL and 57.68mL/min respectively. Out of 94 patients, AC was performed in 45 patients and in the remaining 49 patients AC was not done (control-group), as they were not willing for the same. Baseline patient's characteristics were comparable in both Groups. 22 underwent gastro-cystoplasty (GC) and 25 underwent ileo-cystoplasty (IC). Decline in renal function was observed in 15 (33.3%) patients of AC-group and in 31 (63.3%) patients of control-group. Patients having creatinine ≥1.54mg/dL (P=0.004, sensitivity (S) 63.6% and specificity (s) 90.5%) at baseline and e-GFR ≤46mL/min (P=0.000, S=100% and s=85.7%) at the time of surgery had significantly increased probability of renal function deterioration on follow-up after AC. Conclusion e-GFR ≤46mL/min and creatinine ≥1.54mg/dL at time of surgery could serve as a predictor of renal function deterioration in AC in paediatric patients. |
| first_indexed | 2024-12-17T10:42:30Z |
| format | Article |
| id | doaj.art-ce73d6cb0c314f2797205e75006950b5 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-12-17T10:42:30Z |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-ce73d6cb0c314f2797205e75006950b52022-12-21T21:52:13ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-611944115616210.1590/s1677-5538.ibju.2017.0078S1677-55382018000100156Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children?Prempal SinghAnkur BansalVirender SekhonSandeep NuniaM. S. AnsariABSTRACT Objective To assess cut-off value of creatinine and glomerular filtration rate for augmentation cystoplasty (AC) in paediatric age-group. Materials and Methods Data of all paediatric-patients (<18 years) with small capacity bladder, in whom AC was advised between 2005-2015 were reviewed. All patients were divided in two-groups, AC-group and control-group (without AC). Creatinine and e-GFR were assessed at the time of surgery, at 6 months and at last follow-up. Renal function deterioration was defined as increase in creatinine by ≥25% from baseline value or new-onset stage-3 CKD or worsening of CKD stage with pre-operative-CKD stage-3. ROCs were plotted using creatinine and e-GFR for AC. Results A total of 94 patients with mean-age 8.9 years were included. The mean creatinine and e-GFR were 1.33mg/dL and 57.68mL/min respectively. Out of 94 patients, AC was performed in 45 patients and in the remaining 49 patients AC was not done (control-group), as they were not willing for the same. Baseline patient's characteristics were comparable in both Groups. 22 underwent gastro-cystoplasty (GC) and 25 underwent ileo-cystoplasty (IC). Decline in renal function was observed in 15 (33.3%) patients of AC-group and in 31 (63.3%) patients of control-group. Patients having creatinine ≥1.54mg/dL (P=0.004, sensitivity (S) 63.6% and specificity (s) 90.5%) at baseline and e-GFR ≤46mL/min (P=0.000, S=100% and s=85.7%) at the time of surgery had significantly increased probability of renal function deterioration on follow-up after AC. Conclusion e-GFR ≤46mL/min and creatinine ≥1.54mg/dL at time of surgery could serve as a predictor of renal function deterioration in AC in paediatric patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000100156&lng=en&tlng=enSerumDelayed Graft FunctionCreatinine |
| spellingShingle | Prempal Singh Ankur Bansal Virender Sekhon Sandeep Nunia M. S. Ansari Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children? International Brazilian Journal of Urology Serum Delayed Graft Function Creatinine |
| title | Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children? |
| title_full | Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children? |
| title_fullStr | Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children? |
| title_full_unstemmed | Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children? |
| title_short | Can baseline serum creatinine and e-GFR predict renal function outcome after augmentation cystoplasty in children? |
| title_sort | can baseline serum creatinine and e gfr predict renal function outcome after augmentation cystoplasty in children |
| topic | Serum Delayed Graft Function Creatinine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000100156&lng=en&tlng=en |
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