Relationship between articular and nonarticular manifestations in inflammatory bowel diseases
Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross-sectional study aimed to draw a clinical picture of MSM and their...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=48;epage=48;aulast=Fatemi |
| _version_ | 1811261398721757184 |
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| author | Alimohammad Fatemi Hourossadat Hashemi Jazi Mohammad Hasan Emami Amir Kazemizadeh Hamid Tavakkoli Abbas Smiley |
| author_facet | Alimohammad Fatemi Hourossadat Hashemi Jazi Mohammad Hasan Emami Amir Kazemizadeh Hamid Tavakkoli Abbas Smiley |
| author_sort | Alimohammad Fatemi |
| collection | DOAJ |
| description | Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross-sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD. Materials and Methods: Patients of our IBD cohort between March 2012 and September 2013 were consecutively evaluated. Those with current or past history of any MSM were examined by a rheumatologist. The outcome of interest was different MSMs. Distribution of IBD manifestations between the two groups of patients with (n = 20) and without (n = 253) MSM was compared. Logistic regression analysis was employed to find the relationships of demographic, clinical, and laboratory findings with MSM. Results: Two hundred and seventy-three patients were enrolled. Forty-two patients (15.4%) had extraintestinal manifestations of which twenty patients (7.5%) had at least one MSM. 7/20 patients (35%) versus 22/253 (8.7%) had other extraintestinal manifestations (P = 0.0001). 12/20 patients (57%) had arthritis (polyarthritis, 33% and oligoarthritis, 67%). The most frequent involved joints were knee and ankle observed in 8 (40%) and 7 (35%) patients, respectively. The inflammatory back pain was recorded in 5/20 patients (25%) whereas two patients (10%) had ankylosing spondylitis. In regression analysis, oral aphthous (odds ratio [OR] =8.8 [95% confidence intervals (CI), 1.7–45], P = 0.009) and other extraintestinal manifestations (OR = 5.2 [95% CI, 1.3–20], P = 0.02) were significantly related with arthritis. Conclusion: The most frequent extraintestinal manifestations in patients with IBD were MSM. Knee and ankle were the most frequent involved joints. Extraintestinal manifestations were determinant variables of arthritis. |
| first_indexed | 2024-04-12T19:03:43Z |
| format | Article |
| id | doaj.art-ce745ac267b8466dbb48fb7fd15810a4 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-12T19:03:43Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-ce745ac267b8466dbb48fb7fd15810a42022-12-22T03:20:05ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362016-01-01211484810.4103/1735-1995.183989Relationship between articular and nonarticular manifestations in inflammatory bowel diseasesAlimohammad FatemiHourossadat Hashemi JaziMohammad Hasan EmamiAmir KazemizadehHamid TavakkoliAbbas SmileyBackground: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross-sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD. Materials and Methods: Patients of our IBD cohort between March 2012 and September 2013 were consecutively evaluated. Those with current or past history of any MSM were examined by a rheumatologist. The outcome of interest was different MSMs. Distribution of IBD manifestations between the two groups of patients with (n = 20) and without (n = 253) MSM was compared. Logistic regression analysis was employed to find the relationships of demographic, clinical, and laboratory findings with MSM. Results: Two hundred and seventy-three patients were enrolled. Forty-two patients (15.4%) had extraintestinal manifestations of which twenty patients (7.5%) had at least one MSM. 7/20 patients (35%) versus 22/253 (8.7%) had other extraintestinal manifestations (P = 0.0001). 12/20 patients (57%) had arthritis (polyarthritis, 33% and oligoarthritis, 67%). The most frequent involved joints were knee and ankle observed in 8 (40%) and 7 (35%) patients, respectively. The inflammatory back pain was recorded in 5/20 patients (25%) whereas two patients (10%) had ankylosing spondylitis. In regression analysis, oral aphthous (odds ratio [OR] =8.8 [95% confidence intervals (CI), 1.7–45], P = 0.009) and other extraintestinal manifestations (OR = 5.2 [95% CI, 1.3–20], P = 0.02) were significantly related with arthritis. Conclusion: The most frequent extraintestinal manifestations in patients with IBD were MSM. Knee and ankle were the most frequent involved joints. Extraintestinal manifestations were determinant variables of arthritis.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=48;epage=48;aulast=FatemiArthritisCrohn's diseasemusculoskeletal manifestationsulcerative colitis |
| spellingShingle | Alimohammad Fatemi Hourossadat Hashemi Jazi Mohammad Hasan Emami Amir Kazemizadeh Hamid Tavakkoli Abbas Smiley Relationship between articular and nonarticular manifestations in inflammatory bowel diseases Journal of Research in Medical Sciences Arthritis Crohn's disease musculoskeletal manifestations ulcerative colitis |
| title | Relationship between articular and nonarticular manifestations in inflammatory bowel diseases |
| title_full | Relationship between articular and nonarticular manifestations in inflammatory bowel diseases |
| title_fullStr | Relationship between articular and nonarticular manifestations in inflammatory bowel diseases |
| title_full_unstemmed | Relationship between articular and nonarticular manifestations in inflammatory bowel diseases |
| title_short | Relationship between articular and nonarticular manifestations in inflammatory bowel diseases |
| title_sort | relationship between articular and nonarticular manifestations in inflammatory bowel diseases |
| topic | Arthritis Crohn's disease musculoskeletal manifestations ulcerative colitis |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=48;epage=48;aulast=Fatemi |
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