Theranostics Using Indocyanine Green Lactosomes
Lactosomes™ are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. Lactosomes are polymeric micelles formed by the self-assembly of biodegradable amphiphilic block copolymers composed of hydrophilic polysarcosine and hydrophobic poly-L-lactic acid chains. The p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/15/3840 |
| _version_ | 1797442532452335616 |
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| author | Masaki Kaibori Kosuke Matsui Mikio Hayashi |
| author_facet | Masaki Kaibori Kosuke Matsui Mikio Hayashi |
| author_sort | Masaki Kaibori |
| collection | DOAJ |
| description | Lactosomes™ are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. Lactosomes are polymeric micelles formed by the self-assembly of biodegradable amphiphilic block copolymers composed of hydrophilic polysarcosine and hydrophobic poly-L-lactic acid chains. The particle size can be controlled in the range of 20 to 100 nm. Lactosomes can also be loaded with hydrophobic imaging probes and photosensitizers, such as indocyanine green. Indocyanine green-loaded lactosomes are stable for long-term circulation in the blood, allowing for accumulation in cancer tissues. Such lactosomes function as a photosensitizer, which simultaneously enables fluorescence diagnosis and photodynamic therapy. This review provides an overview of lactosomes with respect to molecular design, accumulation in cancer tissue, and theranostics applications. The use of lactosomes can facilitate the treatment of cancers in unresectable tissues, such as glioblastoma and head and neck cancers, which can lead to improved quality of life for patients with recurrent and unresectable cancers. We conclude by describing some outstanding questions and future directions for cancer theranostics with respect to clinical applications. |
| first_indexed | 2024-03-09T12:43:14Z |
| format | Article |
| id | doaj.art-ce74d2cdaaa645869fad21df85467208 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:43:14Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ce74d2cdaaa645869fad21df854672082023-11-30T22:15:20ZengMDPI AGCancers2072-66942022-08-011415384010.3390/cancers14153840Theranostics Using Indocyanine Green LactosomesMasaki Kaibori0Kosuke Matsui1Mikio Hayashi2Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1191, JapanDepartment of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1191, JapanDepartment of Physiology, Kansai Medical University, Hirakata 573-1191, JapanLactosomes™ are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. Lactosomes are polymeric micelles formed by the self-assembly of biodegradable amphiphilic block copolymers composed of hydrophilic polysarcosine and hydrophobic poly-L-lactic acid chains. The particle size can be controlled in the range of 20 to 100 nm. Lactosomes can also be loaded with hydrophobic imaging probes and photosensitizers, such as indocyanine green. Indocyanine green-loaded lactosomes are stable for long-term circulation in the blood, allowing for accumulation in cancer tissues. Such lactosomes function as a photosensitizer, which simultaneously enables fluorescence diagnosis and photodynamic therapy. This review provides an overview of lactosomes with respect to molecular design, accumulation in cancer tissue, and theranostics applications. The use of lactosomes can facilitate the treatment of cancers in unresectable tissues, such as glioblastoma and head and neck cancers, which can lead to improved quality of life for patients with recurrent and unresectable cancers. We conclude by describing some outstanding questions and future directions for cancer theranostics with respect to clinical applications.https://www.mdpi.com/2072-6694/14/15/3840indocyanine green lactosometumor accumulationphotodynamic diagnosisphotodynamic therapy |
| spellingShingle | Masaki Kaibori Kosuke Matsui Mikio Hayashi Theranostics Using Indocyanine Green Lactosomes Cancers indocyanine green lactosome tumor accumulation photodynamic diagnosis photodynamic therapy |
| title | Theranostics Using Indocyanine Green Lactosomes |
| title_full | Theranostics Using Indocyanine Green Lactosomes |
| title_fullStr | Theranostics Using Indocyanine Green Lactosomes |
| title_full_unstemmed | Theranostics Using Indocyanine Green Lactosomes |
| title_short | Theranostics Using Indocyanine Green Lactosomes |
| title_sort | theranostics using indocyanine green lactosomes |
| topic | indocyanine green lactosome tumor accumulation photodynamic diagnosis photodynamic therapy |
| url | https://www.mdpi.com/2072-6694/14/15/3840 |
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